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논문 기본 정보

자료유형
학술저널
저자정보
Yoon Ji-Won (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University) Jeong Kyoung-Ah (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University) Cho Zang-Hee (Neuroscience Research Institute, Gachon Medical School) Sung Kang-Keyng (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제20권 제1호
발행연도
2006.1
수록면
196 - 201 (6page)

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Electroacupuncture(EA) is commonly used in various diseases. In the present study, the effect of EA in the allergic mouse model was examined. Allergy is generated via immunological mechanism and non-immunological mechanism. Mast cells activated dy those mechanisms get to release various substances such as histamine, leukotrienes, prostaglandin, TNF-$\alpha$, IL-4, IL-6, etc. which induce allergic reactions and the following inflammatory responses. To evaluate the anti-allergic effects of EA, mortality, ear swelling response, vascular permeability and cytokine secretion were investigated in EA group and non-EA group of which mice were compound 48/80-induced allergy model or PCA model. Compound 48/80 induces allergic reaction via non-immunological mechanism and PCA model is generated through the same mechanism with immediate-type(Type1) allergic reaction, one of immunological allergic reactions. EA inhibited compound 48/80-induced ear swelling response but did not inhibit the systemic anaphylaxis. EA also inhibited passive cutaneous anaphylaxis(PCA) activated dy anti-dinitrophenol IgE. In addition, EA inhibited IL-6 and TNF-$\alpha$ secretion from 48 h PCA in mice. These results indicate that EA may be used for the treatment of mast cell-mediated allergic diseases, especially immediate-type(Type 1) allergy and non-immunologically mediated allergy.

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