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자료유형
학술저널
저자정보
Jang, Kyung-Jin (Boryung Pharmaceutical Central Research Institute) Lee, Kyou-Heung (Boryung Pharmaceutical Central Research Institute) Kim, Sang-Lin (Boryung Pharmaceutical Central Research Institute) Park, Dong-Young (Korea and College of Pharmacy, Kangwon National University) Park, Beom-Kyu (Korea and College of Pharmacy, Kangwon National University) Im, Doo-Hyung (Korea and College of Pharmacy, Kangwon National University) Cho, Yong-Joon (Korea and College of Pharmacy, Kangwon National University) Jhoo, Wang-Kee (Korea and College of Pharmacy, Kangwon National University) Kim, Hyoung-Chun (Korea and College of Pharmacy, Kangwon National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제20권 제4호
발행연도
1997.1
수록면
375 - 378 (4page)

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The Chongmyungtang (CMT; the combination of Acorus gramineus, polygala tenuifolia and Poria cocos) has been recognized to possess the preventive effect against several neurologic disorders in human. In this study, we examined the effect of CMT on the three parameters associated with kainic acid (KA)-induced neurotoxicities; seizure/mortality, increased fos-related antigen (FRA) and glial fibrillary acidic protein (GFAP) expression. KA induced vigorous convulsions lasting 4-6 hr. Pretreatments with CMT before KA injection significantly reduced the seizure intensity as well as the mortality. CMT pretreatments also attenuated the KA-induced increase in FRA/GFAP expression in the hippocampus. These results suggest that CMT has a neuroprotective effect against KA-induced neurotoxicities.

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