지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제19권 제6호
- 발행연도
- 1996.1
- 수록면
- 514 - 519 (6page)
이용수
초록· 키워드
오류제보하기
In order to understand the mechanism of action of flavonoids on the drug metabolizing enzyme, cytochrome P450IA1, this study was undertaken to examine the effect of chrysin, morin, myricetin and aminopyrine on the activities of ethoxyresorufin O-deethylase and benzo(.alpha.) pyrene hydroxylase in the liver. In the isolated perfused rat liver that was pretreated with 3-methylcholanthrene (3MC), chrysin, morin, myricetin and aminopyrine inhibited the activity of ethoxyresorufin O-deethylase with concentration dependent manner. The isolated liver perfusion with chrysin, morin, myricetin and aminopyrine showed inhibition on the induction of ethoxyresorufin O- deethylase by 3MC. And also, in mouse liver hepa I cells, 3MC-stimulated the benzo(.alpha.)pyrene hydroxylase activity which was inhibited by chrysin, morin, myricetin and aminopyrine. These results strongly suggested that hydoxylated flavonoids interfered not only the induction of cytochrome P45OIA1 enzymes by 3MC but also the interaction of substrates and enzyme.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Benzo[a]pyrene-induced Modification on p53 and Related Proteins
Environmental Analysis Health and Toxicology
2005 .03
-
Benzo ( a ) pyrene의 면역독성에 미치는 인삼의 영향 ( The Effect of Ginseng on the Immunotoxicity of Benzo ( a ) pyrene )
Environmental Analysis Health and Toxicology
1986 .12
-
Benzo ( a ) pyrene에 의해 유도된 간기능 장해에 미치는 쑥의 효과 ( The Effect of Mugwort Extracts on the Benzo ( a ) pyrene - induced Hepatotoxicity in Rats )
Environmental Analysis Health and Toxicology
1992 .04
-
Benzo ( a ) Pyrene 에 의해 유도된 간장해에 미치는 황련 수침액의 영향 ( Effect of Coptis Rhizoma on Benzo ( a ) pyrene - Induced Hepatotoxicity )
Environmental Analysis Health and Toxicology
1993 .04
-
DNA와 Benzo ( a ) Pyrene 대사물질 결합형성에 미치는 인삼 추출물의 영향 ( Effect pf Ginseng Extracts on the Binding to DNA of Benzo ( a ) Pyrene Metabolites in vitro in Rats )
Journal of Ginseng Research
1989 .06
-
EFFECT OF MONOSODIUM GLUTAMATE ON BRAIN TYROSINE HYDROXYLASE, DOPAMINE-β-HYDROXYLASE, TRYPTOPHAN HYDROXYLASE AND MONOAMINE OXIDASE IN RAT
한국독성학회지
1987 .06
-
Benzo ( a ) pyrene에 의해 유도된 간기능 장해에 미치는 당귀의 효과 ( The Effect of Angelicae gigantis Radix on the Benzo ( a ) pyrene - induced Hepatotoxicity in Rats )
Environmental Analysis Health and Toxicology
1992 .04
-
Benzo〔a〕pyrene 및 Benzo〔a〕pyrene metabolites에 의한 BALB/3T3 세포에서의 DNA-Protein Crosslinks 형성
대한직업환경의학회지
1996 .02
-
DNA damage and expression of p53/p21 HepG2 cells treated with Benzo[a]pyrene
환경독성보건학회 심포지엄 및 학술대회
2005 .11
-
Benzo ( a ) pyrene 유발 DNA 상해 및 복제 억제에 미치는 인삼사포닌의 영향 ( Effects of Ginseng Saponin on DNA Strand Breaks and Replication Inhibition by Benzo ( a ) Pyrene in CHO-K1 Cells )
Journal of Ginseng Research
1992 .12
-
Chinese Hamster Ovary 세포에서 Benzo ( a ) pyrene과 3-Methylcholanthyrene에 의한 DNA 단사절단과 복제 억제에 미치는 Saponin의 영향 ( effects of saponin on DNA strand breaks and replication inhibition induced by S-15-activated Benzo ( a ) pyrene and 3-methylcholanthrene in Chinese hamster ovary cells )
한국환경성돌연변이·발암원학회지
1990 .09
-
Sex-related Differences in Rat Hepatic Cytochromes P450 Expression Following Treatment with Phenobarbital or 3-Methylcholanthrene
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1992 .01
-
벤조피렌의 급성독성 수준에 따른 관리적 방안 연구
한국환경보건학회지
2018 .01
-
인삼 석유에텔 추출물이 흰쥐에서 Benzo(a)pyrene에 의해 유도된 소핵생성의 억제효과
약학회지
1991 .01
-
Benzo(a)pyrene의 돌연변이원성에 대한 유기게르마늄(GE-132)의 항돌연변이 효과
약학회지
1993 .01
-
Application of ³²p-postlabeling assay for the detection of benzo(a)pyrene exposure effect from PALE CHUB (zacco platypus)
환경독성보건학회 심포지엄 및 학술대회
2010 .11
-
Benzo ( a ) Pyrene 대사물질들의 DNA에 대한 Adduct 형성억제에 미치는 Panaxydol의 효과 ( Inhibition of the Formation of Adducts Between Metabolites of Benzo ( a ) Pyrene and DNA by Panaxydol in vivo and in vitro )
Journal of Ginseng Research
1989 .06
-
Benzo(a)pyrene과 Cytochrome P-450의 상호작용에 대한 이론적 연구
대한의생명과학회지
1995 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0