Trichloroethylene 처리한 흰쥐의 간 미크로좀 Alcohol dehydrogenase와 Aldehyde dehydrogenase 활성도에 관한 연구

김기웅; 강선규; 양정선; 박인정; 문영한

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자료유형: 학술저널

저자정보: 김기웅 (한국산업안전공단 산업보건연구원) 강선규 (한국산업안전공단 산업보건연구원) 양정선 (한국산업안전공단 산업보건연구원) 박인정 (한국산업안전공단 산업보건연구원) 문영한 (한국산업안전공단 산업보건연구원)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제4권 제2호

발행연도: 1994.1

수록면: 148 - 156 (9page)

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Chloral hydrate(CH), an intermediate metabolite of trichloroethylene(TRI) is reduced to trichloroethanol(TCE-OH), and is oxidized to trichloroacetic acid(TCA) by the nicotinamide adenine dinucleotide(NAD)-dependent enzymes such as alcohol dehydrogenase(ADH) and aldehyde dehydrogenase(ALDH) in liver. This study was performed to find out the change of activity of ADH and ALDH with increasing amount of TRI. Intraperitoneal injection of TRI were done to the male Sprague Dawely rats(mean body weight, $170{\pm}10g$) in com oil at the dosage of 150, 300, 600 mg/kg for 2 days. The results of experiments are following : 1. The contents of xenobiotic metabolic enzymes in liver are tended to be decreased with increasing amount of, but not significantlly (p>0.05). 2. Activity of ADH in microsome is decreased(p<0.05), and activity of ALDH is increased with amount of TRI(P<0.05). 3. Total trichloro-compounds(TTC) concentration in urine are increased with amount of TRI, but the ratio of between the TCE-OH and the TCA were not shown any critical change. These results suggests that the ALDH in microsome may be related to metabolism of TRI, but ADH was nothing less than the effected to metabolism of TRI.

#Trichloroethylene #Hepatic microsomal cytochrome P-450 #Liver Alcohol dehydrogenase and Aldehyde dehydrogenase #Urinary Total trichloro-compounds

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