지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The effect of various drugs on the stability of the liposomal membrane of phosphatidylcholine and cholesterol was studied, employing the fluorescence self-quenching method. Calcein was entrapped into the phospholipid small unilamellar vesicles and the leakage of the fluorescence probe was monitored on adding the drug to the system. The results of the experiments showed that phenothiazine derivatives, some potent local anesthetics and surface active agents were very effective in inducing the leakage of calcein from the liposome. The leakage-inducing activity of these drug substances has been ascribed to their surface activity and the perturbation of the liposomal membrane by these substances. On the other hand drug substance with low surface activity or without amphiphilic moieties did not show any effect or only small effect on the leakage of calcein from the liposomes. The effect of lipid concentration on the stability of the liposomes was also investigated to show that the higher concentrations of lipid more drug was required to induce the leakage. The effect of surface charges of vesicles was also studied, and the results showed that the charge on the liposomes enhanced the stability of the liposomes against the leakage-inducing activity of these drug substances.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
리포솜 지질막의 성질에 미치는 지질 조성의 영향
약학회지
1994 .01
-
Stability and drug release properties of liposomes containing cytarabine as a drug carrier
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
-
A study of stabilization effect of .alpha.-tocopherol incorporated into liposomal phospholipid membrane
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1990 .01
-
Clinical usefulness of liposomal formulations in cancer therapy: lessons from the experiences of doxorubicin
Journal of Pharmaceutical Investigation
2019 .01
-
Improved Stability of Liposome by Association of Amphiphilic Polyelectrolytes
대한화장품학회지
2007 .01
-
Studies for the osmotic parameter of liposomes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
-
리포좀에 봉입한 5-플루오로우라실 프로드럭의 세포독성, 안정성 및 항암효과
약학회지
1996 .01
-
Effect of Drug Substances on the Microviscosity of Lipid Bilayer of Liposomal Membrane
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1990 .01
-
Effect of phenothiazine derivatives on the thermotropic phase transition of liposomal phospholipid membrane
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1986 .01
-
입체구조적으로 안정화된 리포좀의 특성 및 혈장내 안정성
약학회지
2000 .01
-
Effect of Bovine Serum Albumin on the Stability of Methotrexate-encapsulated Liposomes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1991 .01
-
Gamma camera/MR dual imaging liposome labeled with radioisotope and paramagnetic ions
대한방사성의약품학회지
2017 .01
-
Degradation Kinetics of Water-Insoluble Lauroyl-Indapamide in Aqueous Solutions: Prediction of the Stabilities of the Drug in Liposomes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
DEVELOPMENT OF DRIED LIPOSOMES CONTAUBUBG $\beta$-GALACTO-SIDASE FOR THE DIGESTION OF LACTOSE IN MILK.
한국응용약물학회 춘계학술발표논문집
1996 .01
-
Dual Drug-Loaded Liposomes for Synergistic Efficacy in MCF-7 Breast Cancer Cells and Cancer Stem Cells
대한의생명과학회지
2019 .06
-
PREPARATION AND PHARMACOKINETICS OF METHOTREXATE DELIVERY SYSTEM USING LONG-CIRCULATING LIPOSOMES
한국응용약물학회 춘계학술발표논문집
1996 .01
-
Formulation of Liposome for Topical Delivery of Arbutin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
한국 초.중.고.대학생들에서 약물정보습득의 방법 및 약물오남용의 위험성에 대한 평가
약학회지
2013 .01
-
Targeted and sustained delivery of hydrocortisone to normal and stratum corneum-removed skin without enhanced skin absorption using a liposome gel
한국응용약물학회 춘계학술발표논문집
1996 .01
-
In Vitro and In Vivo Studies of Different Liposomes Containing Topotecan
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0