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Higenamine is a tetrahydroisoquinoline alkaloid which was isolated as a cardiotonic principle from Aconiti tuber. 1.v. injection of higenamine was reported to increase the cardiac output and heart rate and to decrease the blood pressure and the systemic vascular resistance presumably by stimulating the adrenergic ${\beta}-receptors$. The anti-platelet and anti-thrombotic effects of higenamine were investigated in this paper. Higenamine(0.5 mg/ml) showed mild inhibitory effect against collagen induced platelet aggregation in vitro and the inhibito교 effect was increased with the pre-incubation$(5{\sim}30\;min)$ of platelet rich plasma(PRP) with higenamine. With the 30 min incubation, the platelet aggregation was almost completely inhibited. And the oral administration of higenamine$(50{\sim}200\;mg/kg)$ enhanced the survival in the mouse model of thrombosis and that of endotoxic shock. The anti-thrombotic and anti-septic effects of higenamine thus appear to be due to the ${\beta}-agonistic$ and the anti-platelet effects of this compound.
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Determination of blood concentration of higenamine by high pressure liquid chromatography
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
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Identification of Higenamine nad its Metabolites in Rat by Gas Chromatography/Mass Spectrometry
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1993 .01
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Down-regulation of TNF-$\alpha$ and IL-6 by Higenamine is Responsible for Reduction of Infarct Size and Myocardial Ischemic Injury in the Rat
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2001 .01
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Higenamine이 단일심근세포의 Ca-전류 및 활동전압에 미치는 효과
대한생리학회지
1987 .01
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Inhibition of Lipopolysaccaride-induced Inducible Nitric Oxide (iNOS) mRNA Expression and Nitric Oxide Production by Higenamine in Murine Peritoneal Macrophages
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
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Synthesis of Higenamine, A Cardiotonic Principle of Aconite Root
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1984 .01
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Higenamine reduces infarct size and myocardial ischemic injury by modulation of immune cytokines
대한약학회 학술대회
2001 .01
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Pharmacology of enantiomers of higenamine and related tetrahydroisoquinolines
한국응용약물학회 춘계학술발표논문집
2004 .01
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Higenamine 유도체들의 혈소판응집 억제작용
약학회지
1986 .01
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The Effect of Higenamine on Endotoxin-induced Experimental Disseminated Intravascular Coagulation (DIC) in Rats
대한약학회 학술대회
2000 .01
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Heme Oxygenase-l Induction by YS 51, An Analogue of Higenamine, Inhibits Nitric Oxide-Induced Apoptosis of ROS 17/2.8 cells
대한약학회 학술대회
2005 .01
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Protocatechuic acid 및 Gallic acid 유도체들의 항 혈전작용
약학회지
1993 .01
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Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
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The Effect of two 1-naphthylmethyl analogs of Higenamine (YS-49 and YS-51) on LPS-induced Experimental Disseminated Intravascular Coagulation (DIC) in Rats
대한약학회 학술대회
2001 .01
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