지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
The SKINTEX Method is based on a two-compartment physico-chemical model which includes a Biomembrane Barrier in compartment one and an organized macromolecular matrix in compartment two. Test samples absorb onto or permeate through the keratin/collagen Biomembrane Barrier and then can interact with the organized macromolecular matrix. Changes in the integrity of the barrier release a dye indicator: Changes in the matrix can alter its transparency. The sum of these two responses is read spectrophotometrically at 470nm. An early investigation of 950 chemicals and formulations in the SKINTEX System produced results which were 89% concordance to in vivo Draize dermal irritation results obtained with 24-hour occluded application of test samples with-out abrasion and standard scoring. Alkaline materials were analyzed in a specialized SKINTEX AMA Protocol. In this early study, the model did not distinguish nonirritant test materials and formulation with PDII(Primary Dermal Irritation Index)in the range from 0 to 1.2, A High Sensitivity Assay Protocol(HSA)was developed to amplify the changes in both compartments of this model and provide more accurate calibration of these changes. A study of 60 low irritation test samples including cosmetics, household products, chemicals and petro-chemicals distinguished nonirritants with PDII $\leq$ 0.7 for 26 of 30 nonirritants. A second protocol was developed to evaluate the SKINTEX model predictability with respect to human irritation. The Human Response Assay (HRA )has been optimized based on differences in penetration and irritation responses in humans and rabbits. An additional 32 test materials with different mechanisms and degrees of dermal toxicity were evaluated by the HRA. These in vitro results were 86% concordant to human patch test results. In order to further evaluate this model, a Standard Chemical Labelling (SCL) Protocol was developed to optimize this system to predict Draize dermal irritation results after a 4-hour application of the test material. In a study of 52 chemicals including acids, bases, solvents, salts, surfactants and preservatives, the SCL results demonstrated 85% concordance to Draize results for a 4-hour application of test samples on non-abraded rabbit skin. The SKINTEX System, including three specialized protocols, provided results which demonstrated good correlation to the endpoint of dermal irritation in man and rabbits at different application times.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Eye and dermal irritation assessment of eco-friendly farming materials(plant extract) in animal models
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Alternatives to In Vivo Draize Rabbit Eye and Skin Irritation Tests with a Focus on 3D Reconstructed Human Cornea-Like Epithelium and Epidermis Models
Toxicological Research
2017 .06
-
DETECTION OF DERMAL IRRITANT CHEMICALS WITH IN VITRO IRRITATION ASSAY
환경독성보건학회 심포지엄 및 학술대회
2009 .11
-
Validation of Alternatives to Draize Eye Irritation Test in South Korea
한국실험동물학회 학술발표대회 논문집
2009 .08
-
Toxicity Assessment of NCS in Experimental Animals
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Assessment of the dermal and ocular irritation potential of alcohol hand sanitizers containing aloe vera with in vitro and in vivo methods
Molecular & cellular toxicology
2010 .01
-
The Intra-lab Validation Study of the Reconstructed Human Corneal Epithelium Model as an Alternative Method to Eye Irritation Test
한국실험동물학회 학술발표대회 논문집
2013 .02
-
주름방지용 화장품원료의 안점막 자극성과 피부자극성 및 세포독성과의 비교
Toxicological Research
2001 .06
-
Antioxidative Activity and Irritation Test of a Complex Herbal Bath Extracted from Korean Traditional Plants
Toxicological Research
2005 .03
-
Skin and Eye Irritation Tests of Opuntia humifusa Extract in Rabbits
Laboratory Animal Research
2007 .12
-
Eye Irritation, Skin Irritation and Skin Sensitization tests for Aloewhite in Animals
한국응용약물학회 춘계학술발표논문집
1996 .01
-
Antioxidative Activity and Irritation Response of Lespedeza bicolor
Toxicological Research
2005 .06
-
A study on skin and ocular irritation tests of growth factor and cytokine mixtures
예방수의학회지
2019 .01
-
Studies on the Dermal and Ocular Irritation of Prodigiosin Isolated from Zooshikella rubidus
Toxicological Research
2009 .12
-
Employment of cytological evaluation of skin irritancy for Keraskin™, 3D reconstructed human epidermis model
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
a study of recombinant human interferon β ( LB00013 ) for primary eye and skin irritation in rabbits
한국독성학회지
1996 .03
-
Skin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model
Environmental Analysis Health and Toxicology
2014 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0