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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
김동익 (연세대학교 의과대학 병리학교실)
저널정보
대한영상의학회 대한방사선의학회지 대한방사선의학회지 제25권 제4호
발행연도
1989.1
수록면
548 - 563 (16page)

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Iodized oil has been used as a contrast agent in lymphangiography. One of the commercially available compounds is Lipiodol Ultras-fluid(LUF) which contains 38% iodine by weigh. Nakakuma et al(1979) reported that LUF was selectively retained in the hypervascular hepa-tocellular carcinoma when injected directly into the ligated hepatic artery. Since that time it has been widely utilized in the detection as well as the therapeutic attempts of hepatocellular carcinoma where it has been mixed with chemotherapeutic agents or labeled with radioactive I-131 Lipiodol . The apparent safety of this technique repuire confir-mation. The present study was aimd to assess the biodistribution and kinetics of intra-arterially injected I-131 Lipiodol and the histologic changes in canine livers. It was also to verify the safety of this technique in clinical applications. Radioactive iodized oil was obtained by simple exchange method. 518$\pm$19 MBq(14m Ci about 1 m, Ci/kg body weigth) of I-131 Lipiodol was injected intra-arterially in 12 dogs as a experimental group. Serial count rates over the livers under gamma camera were measured and then it was compared with quantitative analysis of radioactivites distributed in liver lung spleen kidney thyroid bile and circulating blood using dose calibrator after sacrifice at various time inter-vals. Cumulative radiation doses wee calculated by Quimby method. The effect of I-131-Lipi-odol on hepatic function were analysed by serial liver function tests after intrahepatic injection of I-131-Lipiodol and compared with preinjection values. Liver tissue obtained after sacrifice were stained with hematoxylin-eosin Oil red-O and electron microscopic examinations were performed. the results were summerized as follows: 1. Intra-arterially injected I-131-Lipiodol was trapped first in the liver and gradually cleared from the liver upto 50% in the initial 1 week. It was excreted through urine(36.4%) and stool(6.5%) in the same period. 2. I-131-Lipiodol were consistently identified within the hepatocyts and sinusoids as well as bile duct epithelium within the initial 1 weeks and minor foreign body reaction and lipid granuloma were appeared at the time of 1-4 weeks. 3. Transient and slight elevation of hepatic enzymes were developed in 7/12 dogs after postinjection of 1-4 weeks and returned to normal level of preinjection state, 4. The radiation dosimetry measured by means of the biodistribution and clearance data disclosed that the radiation dose to liver was 13.7 Gy; thyroid gland 3.7Gy; lung 2Gy; remained body organs 0.1-0.3Gy respectively It could be predicted that the equivalent dose in clinical application distributes in the critical organs below the tolerance dose levels It ws concluded that the intra-arterially injected I-131 Lipiodol was mainly distributed in liver and supposed to be metabolized within the hepatocytes; the main excretion route is urine; and the diagnostic and therapeutic purpose of I-131 Lipiodol injection for hepatocellular carcinoma could be safely performed.

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