지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In order to attain a sustained release at targeted organs in a prolonged time which can reduce the side effects and maximize the therapeutic effect, aclarubicin (ACL) was entrap ped into liposomes of different lipid compositions using Microfluidizer, and dry liposomes were prepared by lyophilization. The dry aclarubicin-entrapped liposomes were evaluated in terms of mean particle size and size distribution, entrapment efficiency and in vitro drug release profile. The Entrapment efficiency of liposome, when the concentration of aclarubicin and lipid were 0.5 to 1.0mg/ml and $200{\mu}mol$/ml, respectively, was over 80% using Microfluidizer, in contrast to 70% of entrapment efficiency using hand-shaking method. Mean particle size and size distribution of aclarubicin-entrapped liposomes of various lipid compositions did not change considerably by the freeze drying. The range of particle size was between 80 and 200nm. Among aclarubicin-entrapped liposomes, ACL-liposome of PC/DPPC/CH0L/TA displayed the most significant sustained release. The addition of DPPC appeared to be favorable for the control of release. In general, aclarubicin entrapped in liposomes was less stable than free aclarubicin either in pH 7.4 phosphate buffer or in human plasma. Formulation I($t_{1/2}$, 20.3 hr) devoid of lipid additive was the most unstable in the phosphate-buffer solution while formulation II($t_{1/2}$, 40.7 hr) with cardiolipin was the most stable. Half lives of aclarubicin-entrapped liposomes in human plasma were 43.2, 50.7, 35.9 and 35.3 hr for formulation I. II, III and IV, respectively, in contrast to 57.8 hr for free aclarubicin.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
리포좀에 봉입된 아클라루비신의 약물동태, 세포독성, 항암효과 및 비장/혈구 세포독성
약학회지
1998 .01
-
리포좀에 봉입한 5-플루오로우라실 프로드럭의 세포독성, 안정성 및 항암효과
약학회지
1996 .01
-
Gamma camera/MR dual imaging liposome labeled with radioisotope and paramagnetic ions
대한방사성의약품학회지
2017 .01
-
Improved Stability of Liposome by Association of Amphiphilic Polyelectrolytes
대한화장품학회지
2007 .01
-
DEVELOPMENT OF DRIED LIPOSOMES CONTAUBUBG $\beta$-GALACTO-SIDASE FOR THE DIGESTION OF LACTOSE IN MILK.
한국응용약물학회 춘계학술발표논문집
1996 .01
-
리포좀에 봉입된 5-플루오로우라실 프로드럭의 약물 동태 및 장기 분포
약학회지
1996 .01
-
PREPARATION AND PHARMACOKINETICS OF METHOTREXATE DELIVERY SYSTEM USING LONG-CIRCULATING LIPOSOMES
한국응용약물학회 춘계학술발표논문집
1996 .01
-
마이크로플루다이저를 사용한 MLV liposome 형성에 관한 연구
대한화장품학회지
1995 .01
-
Stability and Formation Mechanism for MLV liposomes with Phospholipid Film by Use of the Microfluidizer
대한화장품학회지
1996 .01
-
Effect of saltss on the entrapment of calf thymus DNA into liposomes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
-
염의 농도에 따른 DOPC 리포좀의 안정성에 관한 연구
대한화장품학회지
2011 .01
-
Gene Transfer Into Human Chondrocyte Derived Cells Using A Liposome Mediated Transfection System
대한정형외과학회지
2001 .04
-
Application of PEG-coated liposomes for oral delivery of peptide: Effect of liposome composition on the gastrointestinal absorption of rhEGF
대한약학회 학술대회
2001 .01
-
The study on stabilization of Retinol-Nanoemulsion using Skin Lipid Matrix(SLM)
대한화장품학회 학술대회
2003 .01
-
리포솜 지질막의 성질에 미치는 지질 조성의 영향
약학회지
1994 .01
-
Studies for the osmotic parameter of liposomes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
-
Preparation and Gene Delivery of Alkaline Amino Acids-Based Cationic Liposomes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Formulation of Liposome for Topical Delivery of Arbutin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Effect of Bovine Serum Albumin on the Stability of Methotrexate-encapsulated Liposomes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1991 .01
-
Relative Bioavailability of Coenzyme Q10 in Emulsion and Liposome Formulations
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0