지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제6권 제1호
- 발행연도
- 1998.1
- 수록면
- 20 - 24 (5page)
이용수
초록· 키워드
오류제보하기
In the present study, we tested whether lead intoxication induces change of the thiamine content and the seizure threshold in rats and the changes of seizure threshold are related to the changes of thiamine status. It was also tested whether administration of excessive thiamine could reverse the toxic manifestation of lead in rats. Four groups of Wistar rats were prepared: 1) control group, 2) lead treated group, 3) lead plusthiamine treated group, and 4) thiamine deficient group. Each group of animals was divided into three subgroups based on age: 3, 7 and 16 weeks. In each group, thresholds of electroshock seizure and thiamine contents in brain regions including telencephalon, brain stem, cerebellum were measured. Thiamine contents in brain regions of the lead treated group were significantly lower than those of the control group and thiamine treatment reversed the decrease back to the control level. Thresholds of the electroshock seizure of the lead treated group in 3, 7 week old rats and those of thiamine deficient group in 3 week old rats were significantly lower than those of the control group. These observations were reversed by the supplementation with thiamine. These results from the present study suggest that increased seizure sensitivity induced by lead intoxication in rats may be mediated at least in part through the changes of thiamine status.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Thiamine deficiency as one of the mechanisms for neurotoxicity induced by lead intoxication in rats.
한국응용약물학회 추계심포지움자료집
1995 .01
-
Effect of lead intoxication and thiamine deficiency on myelin compositions and seizure threshold in the rats.
한국응용약물학회 춘계학술발표논문집
1995 .01
-
Effect of Lead Intoxication on Thiamine Content and Transketolase Activity in the Brain of Rats
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1995 .01
-
Studies on the possible role of thiamine in the central nervous system
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1980 .01
-
질산치아민의 제조조건과 치아민 모노염류의 제제학적 안정성
약학회지
1997 .01
-
Thiamine Deficiency in a Child with Short Bowel Syndrome and Review
Pediatric Gastroenterology, Hepatology & Nutrition
2019 .01
-
알코올 중독자 및 장기 입원 환자에서 thiamine 결핍의 빈도
대한내과학회지
2002 .01
-
외과계 중환자실 환자에서 티아민 결핍에 의해 발생한 습성 각기병과 베르니케 뇌병증
Acute and Critical Care
2013 .01
-
Cardiovascular beriberi: rare cause of reversible pulmonary hypertension
영남의대학술지
2014 .01
-
Studies on the interaction of thiamines and cyclodextrins
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1983 .01
-
Characteristics of Neuronal Dysfunction induced by Thiamine-Deficient Feeding
한국응용약물학회 추계학술발표논문집
2004 .01
-
개의 진행성 마비에 Thiamine과 Prednisolone의 효과
대한수의사회지
1980 .01
-
췌십이지장절제술 후 발생한 지속적인 구토증과 Wernicke 뇌병증
신경정신의학
2007 .01
-
Wernicke's encephalopathy in a child with high dose thiamine therapy
Clinical and Experimental Pediatrics
2014 .01
-
수술 후 경정맥 영양공급과 일시적인 경구영양법을 받은 환자에서 발생한 베르니케 뇌병증 1예-증례 보고-
Acute and Critical Care
2010 .01
-
Combined Vitamin C, Hydrocortisone, and Thiamine Therapy for Surgical Critically Ill Patients with Septic Shock
대한외과학회 학술대회 초록집
2018 .11
-
경련과 자연발생 엽상뇌출혈의 임상적연구
Annals of Clinical Neurophysiology
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0