국소 진행성 두경부암 환자에서의 Docetaxel과 Cisplatin 유도화학요법

조은희; 조근혁; 송영봉; 최익성; 최재원; 남승현; 김봉석

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자료유형: 학술저널

저자정보: 조은희 (서울보훈병원 내과) 조근혁 (서울보훈병원 내과) 송영봉 (서울보훈병원 내과) 최익성 (서울보훈병원 내과) 최재원 (서울보훈병원 내과) 남승현 (서울보훈병원 내과) 김봉석 (서울보훈병원 내과)

저널정보: 대한두경부종양학회 대한 두경부 종양 학술지 대한 두경부 종양 학술지 제21권 제2호

발행연도: 2005.1

수록면: 126 - 131 (6page)

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Objectives: To evaluate the efficacy and safety of induction chemotherapy with docetaxel and cisplatin in locally advanced head and neck cancer. Materials and Methods: Between June 1998 and December 2004, 30 patients were enrolled and among them, 20 patients were evaluable. Patients were treated with docetaxel $75mg/m^2$ and cisplatin $60mg/m^2$ on day 1 every 21 days. Results: The median age was 71(range 54-80) years old. All 20 patients were male. Nineteen patients had pathologically squamous cell carcinoma and 1 had undifferentiated carcinoma. Fourteen of 20 patients(70%) demonstrated an objective response with two(10%) achieving a complete clinical response and eleven(60%) a partial response. The median response duration was 5.3(1.6-32.1) months and the median time to progression was 5.6(1.4-33.8) months. The median overall survival of all patients was 14(range 2.2-34) months. The median overall survival of responders was 17.5(range 5-34) months and that of non-responders was 3.2(range 2.2-23) months, but it was not statistically significant(p=0.106). During a total of 92 cycles, granulocytopenia worse than CTC(Common toxicity criteria) grade 2 occurred in 6%, thrombocytopenia in 2%, and anemia in 3%, respectively. Non-hematologic toxicities were minor and easily controlled. Conclusion: The induction chemotherapy of docetaxel and cisplatin has moderate efficacy with acceptable toxicities in patients with locally advanced head and neck cancer.

#국소 진행성 두경부암 #유도화학요법

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