지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 1,552 - 1,556 (5page)
이용수
초록· 키워드
오류제보하기
Silymarin has been known to exert anti-tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that silymarin induced apoptosis in androgen-independent prostate cancer DU145 cells as confirmed by DNA fragmentation. Our data demonstrated that silymarin-induced apoptotic cell death was accompanied by activation of caspase-3 and subsequent cleavages of its substrates, poly(ADP-ribose) polymerase (PARP) in a time- and concentration-dependent manner. Also, silymarin-induced apoptotic mechanism of DU145 cells involved the induction of Par-4 protein expression. Taken together, these results suggest that silymarin induces the activation of caspase-3, degradation of PARP, increase of Par-4 expression, and eventually leads to apoptotic cell death.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
전립선 암세포에서 silymarin의 고사 유도 효과 및 기전 연구
동의생리병리학회지
2005 .12
-
Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Induction of apoptosis and inhibition of growth in human gastric cancer by silymarin
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Immunomodulatory effects of silymarin after subacute exposure to mice: A tiered approach immunotoxicity screening
Journal of Pharmacopuncture
2018 .01
-
Anticancer Effect of Silymarin on Breast Cancer Cells through Inhibition of Akt and MAPK Pathway Expression
한국실험동물학회 학술발표대회 논문집
2017 .08
-
엉겅퀴 추출물 실리마린의 피부 미백효과
대한화장품학회지
2009 .01
-
Protective effect of silymarin in streptozotocin-induced diabetic dyslipidaemia in rats
Oriental pharmacy and experimental medicine
2010 .01
-
Silymarin, a flavonoid antioxidant, protects streptozotocin-induced lipid peroxidation and β-Cell damage in rat pancreas
Oriental pharmacy and experimental medicine
2008 .01
-
Effects of silymarin on liver regeneration induced by partial hepatectomy (PH) in rats : immunohistochemical study
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Silymarin as a novel therapeutic alternative for salivary gland cancer treatment by targeting ERK1/2-Bim signaling cascade
한국실험동물학회 학술발표대회 논문집
2015 .08
-
The Effect of Silymarin Treatment on the Oral Disposition of Rosuvastatin
대한임상약리학회 학술대회
2006 .01
-
Polyoxyl 40 Hydrogenated Castor Oil이 실리마린과 우루소데옥시콜린산 복합제제중 실리마린의 용해성 및 생체이용률에 미치는 영향
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1997 .01
-
Preventive effect of silymarin on the restraint-induced liver injury via inhibition of oxidative stress and inflammation in BALB/c mice
한국실험동물학회 학술발표대회 논문집
2018 .07
-
흰쥐의 Thioacetamide에 의한 간장해에 미치는 Silymarin 과 염산 Promethazine의 약물 상호작용에 관한 연구
약학회지
1979 .01
-
The Therapeutic Effect of Korean herbal Rosacea Cream and Silymarin in LL-37-induced RosaceaMouse Model
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Silymarin's Protective Effects and Possible Mechanisms on Alcoholic Fatty Liver for Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
-
Alterations of Mast Cells and $TGF-{\beta}1$ on the Silymarin Treatment for $CCl_4$-Induced Hepatic Fibrosis
한국수의병리학회 학술발표논문집
2004 .01
-
실리마린의 간보호 작용에 미치는 쿠쿠마 추출물의 영향
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0