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논문 기본 정보

자료유형
학술저널
저자정보
최명애 (College of Nursing, Seoul National University) 변영순 (College of Nursing, Ewha Woman's University) 황애란 (College of Nursing, Yonsei University) 김희승 (College of Nursing, Catholic University) 홍해숙 (Department of Nursing, Kyoungbuk University) 최스미 (College of Nursing, Seoul National University) 서화숙 (Department of Nursing, Inha University) 이경숙 (Department of Nursing, Wonju National College) 박미정 (Department of Nursing, Daebul University) 신기수 (Redcross College of Nursing) 안경주 (College of Nursing, Seoul National University) 이윤경 (College of Nursing, Seoul National University) 임지회 (College of Nursing, Seoul National University)
저널정보
한국기초간호학회 기초간호자연과학회지 기초간호자연과학회지 제4권 제1호
발행연도
2002.1
수록면
85 - 99 (15page)

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초록· 키워드

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This study was conducted to determine whether low intensity regular exercise following steroid treatment could attenuate steroid-induced muscle atrophy. Thirty-eight Sprague-Dawley rats weighing $165{\sim}175g$ were divided into six groups ; control group(C), dexamethasone administration group(D), sedentary normal saline administration group(C+Se), exercise after normal saline administration group(C+Ex), sedentary group after dexamethasone administration(D+Se), exercise group after dexamethasone administration(D+Ex). Either dexamethasone(5mg/kg) or normal saline was injected for 7days accordingly. Exercise was started at 10m/min on the $10^{\circ}$ grade treadmill and gradually increased up to 15m/min by the 7th day for 60minutes/day($20min{\times}3$). The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSS WIN 9.0 program. Body weight, muscle weight and myofibrillar protein content of both plantaris and gastrocnemius, Type I, II muscle fiber cross-sectional area of plantaris, and Type II muscle fiber cross-sectional area of gastrocnemius in D group were significantly lower than those of C group(p<0.05) respectively. Hindlimb muscle weight, myofibrillar protein content of both plantaris and gastrocnemius. Type I muscle fiber cross-sectional area of soleus and Type I, II muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of D+Se group. Myofibrillar protein content of both plantaris and gastrocnemius, Type I muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of C+Se group. Based on these results, it is suggested that regular low-intensity exercise during recovery period after steroid treatment might facilitate the recovery from steroid-induced muscle atrophy.

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