지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Purpose/Methods: Repeated administration of methamphetamine (METH) produces high extracellular levels of dopamine (DA) and subsequent striatal DA terminal damage. The effect of MK-801, a noncompetitive N-methyl-D-aspartate receptor antagonist, on METH-induced changes in DA transporter (DAT) and DA release evoked by an acute METH challenge was evaluated in rodent striatum uslng $[^3H]$]WIN 38,428 ex vivo auto-radiography and in vivo microdialysis. Results: Four injections of METH (10 mg/kg, i.p.), each given 2 h apart, produced 71% decrease in DAT levels in mouse striatum 3 d after administration. Pretreatment with MK-801 (2.5 mg/kg, i.p.) 15 min before each of the four METH injections protected completely against striatal DAT depletions. Four injections of MK-801 alone did not significantly change striatal DAT levels. Striatal DA release evoked by an acute METH challenge (4 mg/kg, i.p.) at 3 d after repeated administration of METH in rats was decreased but significant compared with controls, which was attenuated by repeated pretreatment with MK-801. Also, repeated injections of MK-801 alone attenuated acute METH-induced striatal DA release 3 d after administration. Conclusion: These results suggest that repeated administration of MK-801 may exert a preventive effect against METH-induced DA terminal injury through long-term attenuation of DA release induced by METH and other stimuli.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
메스암페타민 자발섭취가 흰쥐 뇌조직 중 세로토닌 수용체에 미치는 영향
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2001 .01
-
Panax ginseng Attenuates MK-801-Induced Stereotypy in Mice
스트레스硏究
2009 .12
-
MK-801 투여에 의한 몰핀의존성랫드 뇌선초체중 도파민신경절달물질의 변화
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1998 .01
-
Methanol extract from radix of Glycyrrhizae uralensis attenuate methamphetamine-induced hyperlocomotor activity
대한한의학방제학회지
2014 .01
-
Inhibitory Effects of Ginseng Total Saponin on Methamphetamine-induced Striatal Dopamine Increase in Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
흰쥐에서 출생 전의 Nitric Oxide Synthase 억제제의 노출이 출생 후의 MK-801에 의해 유도된 행동 민감성에 미치는 영향
신경정신의학
2007 .01
-
척수 손상 백서에서 MK801 투여가 체성감각 유발전위 및 척수 조직에 미치는 효과
대한신경외과학회지
2000 .01
-
Inhibition by MK-801 of Morphine-Induced Conditioned Place Preference and Postsynaptic Dopamine Receptor Supersensitivity in Mice
한국응용약물학회 춘계학술발표논문집
1996 .01
-
Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Effects of Olanzapine on Gene Expression Changes in MK-801-induced Neurotoxicity Using a High-density DNA Microarray
Molecular & cellular toxicology
2007 .01
-
Methamphetamine and MDMA (3,4-methylenedioxymethamphetamine) Induce Apoptosis in Both Human Serotonergic and Dopaminergic Cell Lines
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2003 .01
-
지연성 운동장애의 예방과 치료에 대한 MK-801의 효과
생물정신의학
1997 .01
-
Electroencephalographic Power Spectral Profile in a Rat Model of Schizophrenia
Clinical Psychopharmacology and Neuroscience
2009 .01
-
changes in dopamine receptor binding by mk-801 in morphine - dependent rats
한국독성학회지
1998 .03
-
Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats
Yonsei Medical Journal
2018 .01
-
자궁경부의 전암 병변 및 침윤성암종에서 Mikdine의 발현 양상
Journal of Pathology and Translational Medicine
2007 .01
-
국소뇌허혈에서 NMDA 수용체 길항제가 국소 뇌포도당 대사율에 미치는 영향
대한핵의학회지
1995 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0