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Hypofractionated Radiation Therapy for Early Glottic Cancer - Preliminary Results -
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초기 성문암 환자에서의 소분할 조사법을 이용한 방사선치료 - 예비적 결과 -

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Type
Academic journal
Author
Wu Hong-Gyun (서울대학교 의과대학 치료방사선과학교실, 서울대학교 의학연구원 방사선의학연구소) Hong Semie (서울대학교 의과대학 치료방사선과학교실) Shin Seong Soo (삼성서울병원 치료방사선과) Park Charn Il (서울대학교 의과대학 치료방사선과학교실, 서울대학교 의학연구원 방사선의학연구소)
Journal
대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제19권 제4호 SCOPUS
Published
2001.1
Pages
301 - 305 (5page)

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Hypofractionated Radiation Therapy for Early Glottic Cancer - Preliminary Results -
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Purpose : This study was peformed for the evaluation of the feasibility and toxicity of hypofractionated radiation therapy for early glottic cancer Methods and Materials : From February 1999 to February 2000, 20 patients with Histologically confirmed Stage I, II glottic cancer were enrolled into this study. There were 18 males and 2 females, the median age of the patients was 59 years. The distribution of stage distribution was as fellows; T1aN0-16 patients, T1bN0-1 patient, T2N0-3 patients. Eighteen patients underwent laryngomicroscopic biopsy only, and two patients underwent laser cordectomy. All patients received radical radiation therapy (2.5 Gy per fraction, 24 fractions, total 60 Gy). Median duration of treatment was 36 days (range $31\~45\;days$). Results : Radiation therapy were well tolerated. Most common acute reactions were odynophagia and hoarseness, and these reactions resolved after radiation therapy. There were one case of RTOG grade 3 odynophagia $(5\%)$, six cases of grade 3 hoarseness $(30\%)$. Response of radiation therapy was evaluated one month after completion of treatment. All patients revealed complete response. During follow up, total three cases of treatment failure were detected. two cases were local recurrence in 10 and 13 months of radiation therapy and one case was local recurrence and distant metastasis in 2 months of radiation therapy. Conclusion : This hypofractionated radiation therapy schedule was feasible and effective for control of early glottic cancer But longer follow up time would be required to assess the long-term disease control and the late complication by shortening radiation therapy duration.

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