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Recently, studies on missile antitumor drugs, which selectively act on tumor cell and display drug effects, have been performed. These missile antitumor drugs which can increase drug effects and decrease side effects, are ideal medication method. Lectin has been reported as tumor cell specific binding protein and tannin as antitumor substance. In this study, we studied inhibition of melanoma metastasis by lectin-conjugated ellagitannin and used praecoxin A as ellagitannin source. Mouse melanoma cell, B16-F10, was injected into the sole of forefoot of C57BL/6 mouse, and after administration with drug, the number of pulmonary tumor colony was counted. The administration of praecoxin A, lectin-praecoxin A mixiture, and lectin-conjugated praecoxin A was started after amputation of established tumor foci at right forefoot of mice and continued for 3 weeks with i.p. injection of one of those drugs A every 24 hours. Lectin-praecoxin A mixture, and lectin-conjugated praecoxin A significantly reduced the number of spontaneous pulmonary metastasis. Exposure to 5 mg/kg of lectin-praecoxin A mixiture and lectin-conjugated praecoxin A produced a statistically significant 38.3%, 41.8% reduction in the number of remaining pulmonary metastasis. These results suggest that metastasis inhibition by lectin-praecoxin A mixiture and lectin-conjugated praecoxin A are better than that of praecoxin A.
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Lectin-conjugated Ellagitannin의 혹색종에 대한 항암활성
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Macrophage의 IL-1$\beta$Gene Expression 대한 Lectin-conjugated Ellagitannin의 효과
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Immune activity effects by the Lectin-conjugated praecoxin A
대한약학회 학술대회
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IL-12 expression effects of macrophage by the lectin-conjugated praecoxin A
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Immuno Activation of Lectin-Conjugated Praecoxin A on IL-6, IL-12 Expression
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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Wheat Germ Agglutinin-conjugated Praecoxin A의 제작 및 특성
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Effects of Lectin-conjugated Ellagitannin on Inhibition of Melanoma Metastasis
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천연물에서 단리한 식물정제 탄닌의 항암효과 및 생물학적 반응 조절 물질로서의 기능 검색
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Effects of Lectin-conjugated Ellagitannin on the IL -1$\beta$ gene expression of macrophage
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Preparation of WGA lectin-conjugated ellagitannin and its application
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Encapsulation of lectin-conjugated ellagitannin(LET) into sterically stabilized liposomes
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솔비나무 유래 렉틴의 정제 효율
약학회지
2007 .01
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겨우살이 Lectin의 항당뇨 효과
대한의생명과학회지
2000 .06
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Studies on Lectins from Marine Shells (III) : Screening of Lectin-like Agglutinins from Marine Shells
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1986 .01
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Isolation and Characterization of $\beta$-Galactoside Specific Lectin from Korean Mistletoe (Viscum album var. coloratum with Lactose-BSA-Sepharose 4B and Changes of Lectin Conformation
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1998 .01
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