지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The hot water and mathanol extracts of Artemisia argyi showed considerable cytotoxicities against H9(ATCC HTB 176) cancer cell with IC50 values of $48.6{\;}\mu\textrm{g}/ml$ and $51.9{\;}\mu\textrm{g}/ml$, respectively. These cytotoxicities were found to be dependent on the extract concentrations and culture days. CuZnSOD and MnSOD activities were significantly increased in the cytoplasm and mitochondria fractions of cancer cell, and media in the presence of Artemisia argyi. Such enhanced SOD activities were generally in the range of two to threefolds. In contrast to SOD, catalase and glutathione peroxidase activities were not detected at all. These results suggest that Artemisia argyi have generated $O_2^-$ in the mitochondria and cytoplasm of H9 cancer cell with concurrent induction of CuZnSOD and MnSOD in situ, which dismutate $O_2^-{\}to{\;}H_2O_2$. Without coordinated actions of catalase and/or glutathione peroxidase $H_2O_2$ is easily converted to very toxic OH and these reactive oxygen species together might have induced necrosis and/or apoptosis of H9 cell.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
황해쑥 추출정제물 SD-994의 L1210암세포에 대한 세포독성과 항산화효소의 유발
약학회지
2000 .01
-
황해쪽 물분획물의 L1210세포에 대한 세포독성과 항산화효소 활성변화
약학회지
2002 .01
-
Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals
한국실험동물학회 학술발표대회 논문집
2017 .08
-
골성 관절염 환자에서 적혈구 및 활액의 superoxide dismutase, catalase 및 glutathione peroxidase 활성
대한정형외과학회지
1994 .02
-
Resveratrol induces the apoptosis associated with activation of caspases in HTB-41 human salivary gland epidermoid carcinoma cells
Oral Biology Research
2016 .01
-
홍삼 투여가 방사선에 조사된 생쥐 간세포의 Superoxide Dismutase , Peroxidase 및 Catalase 활성도에 미치는 영향 ( The Effect of Red Ginseng Extracts on the Superoxide Dismutase , Peroxidase and Catalase Activities in the Liver of Gamma Ray Irradiated Mice )
Journal of Ginseng Research
1993 .04
-
Vascular Cell Responses against Oxidative Stress and its Application
International Journal of Vascular Biomedical Engineering
2004 .01
-
태충(太衝) 애엽(艾葉) 약침(藥鍼)이 일과성(一過性) 전뇌(前腦) 허혈(虛血) 손상(損傷)에 미치는 효과(效果)
Korean Journal of Acupuncture
2005 .01
-
만성폐쇄성 폐질환 환자에서 적혈구 항산화효소의 변화
Tuberculosis and Respiratory Diseases
1997 .01
-
Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines
Cancer Research and Treatment
2011 .01
-
Functions of flavonoids in three Korean native varieties of Artemisia species
Journal of Biomedical and Translational Research
2020 .01
-
Effects of Oxidative Stress on Apoptosis and Antioxidant Enzyme Levels
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1996 .01
-
Apoptotic Activity of Curcumin and EF-24 in HTB-41 Human Salivary Gland Epidermoid Carcinoma Cells
International Journal of Oral Biology
2015 .01
-
Neurotoxicant (fenitrothion) alters superoxide dismutase, catalase, and peroxidase activities in Chironomus riparius Mg.
한국환경성돌연변이·발암원학회지
2001 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0