지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Camptothecin (CPT) has been known to induce apoptosis in various cancer cell lines. To examine the intracellular apoptotic death signal initiated by CPT, we investigated the possible connection between caspase-3 activation and GSH depletion during CPT-induced apoptosis in HL-60 cells. Treatment of cells with $1{\;}{\mu}M$ CPT induced PARP cleavage accompanied by DNA fragmentation. z-VAD-fmk, a caspase-3 inhibitor, blocked the CPT-induced DNA fragmentation. Pretreatment of cells with N-acetylcysteine, a precursor of GSH biosynthesis, failed to inhibit CPT-induced PARP celavage and DNA gragmenatation. No significant changes in GSH depletion is not essential for caspase activation during CPT-induced apoptosis. We also investigated whether CPT-induced apoptosis is associated with changes of the levels of Bax and Bcl-2, two proteins involved in the control of apoptosis. Bcl-2 levels exhibited a late decrease compared with the kinetics of DNA fragmentation, whereas Bax levels increased more rapidly after CPT treatment. These results suggest that Bax plays more important role than Bcl-2 in inducing DNA fragmentation and may function upsteam of proteolytic activation of caspase-3 pathway in CPT-induced apoptosis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Camptothecin으로 유발된 생쥐 3T3 섬유모세포의 세포자멸사에서 Bcl-2, Bax, Cytochrome c 및 Caspase-3의 발현
Journal of Pathology and Translational Medicine
2002 .01
-
위암 세포주에서 항암 화학제 Camptothecin에 의한 Apoptosis
Annals of Surgical Treatment and Research
1998 .12
-
연령, 성별 및 신체부위에 따른 전류 지각 역치
대한근전도 전기진단의학회지
2009 .01
-
Expression of Bcl-2 and Caspase-3 Proteins Related to Apoptosis in Human Leukemia K-562 Cells
대한의생명과학회지
2005 .09
-
Induction of the apoptosis of HL -60 leukemia cells by Scytosiphon lomentaria
한국응용약물학회 추계학술발표논문집
2003 .01
-
Rice Bran Phytic Acid Induced Apoptosis Through Regulation of Bcl-2/Bax and p53 Genes in HepG2 Human Hepatocellular Carcinoma Cells
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
임파부종 환자에서 복합적 임파물리치료의 효과 예측: 림프신티그라프 검사 중 시행한 임파마사지의 유용성
Annals of Rehabilitation Medicine
2004 .01
-
천초근 추출물이 HL-60 세포주의 세포자멸사 기전에 미치는 영향
동의생리병리학회지
2008 .01
-
까마귀쪽나무(Litsea japonica)의 HL-60 백혈병 세포 Apoptosis 유도효과
약학회지
2009 .01
-
백혈병 세포주 HL-60에서 과루실 세포고사 유도 효과
동의생리병리학회지
2005 .01
-
Ginsenoside Rh2 Induces Apoptosis via Activation of Caspase-1 and -3 and Up-Regulation of Bax in Human Neuroblastoma
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with MitochondrialDysfunction
Cancer Research and Treatment
2002 .01
-
Arsenic Trioxide Induces Apoptosis in Human Colorectal Adenocarcinoma HT-29 Cells Through ROS
Cancer Research and Treatment
2006 .01
-
Compound K, Ginseng Saponin Metabolite, Induces Apoptosis in Human Monocytic Leukemia cells
한국응용약물학회 추계학술발표논문집
2003 .01
-
백혈병 세포주 HL-60에서 과루실(瓜蔞實)의 세포고사 유도 효과
한국전통의학지
2006 .01
-
Nanoparticle Realgar Powders Induce Apoptosis in U937 Cells through Caspase MAPK and Mitochondrial Pathways
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Camptothecin 유도체의 Human Topoisomerase I-DNA 복합체에 대한 Docking 연구
약학회지
2009 .01
-
혈액암 세포에서 부자(附子) 추출물의 Apoptosis 유도 효과
동의생리병리학회지
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0