지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
To reveal the inhibitory mechanism of NO-dependent vasorelaxation by quinone derivatives (OQ1 and OQ21), we have compared the generation of free radicals by oxidative stress and the formation of cellular adducts by arylation. First, we measured oxygen consumption by quinone derivatives as a marker of oxidative stress in order to investigate whether these quinone compounds could generate reactive oxygen species. Both OQ1 and OQ21 generated free radicals and OQ21 was more potent. These results suggested that free radicals be involved in the inhibition of vasorelaxation by quinones. Next, we measured the binding capacity of quinone derivatives with intracellular GSH and protein thiols (-SH) in order to investigate whether these quinones have arylation capacity. Compared to positive control groups (menadione), both OQ1 and OQ21 depleted intracellular GSH and protein thiols very slightly. These compounds have low toxicities in mammalian tissues. From these results, we concluded that the inhibition of vasorelaxation by quinone derivatives (OQ1, OQ21) may be cuased by generation of free radicals.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
흰쥐 뇌에서의 Lipopolysaccharide-유도 산화적 스트레스에 대한 OQ21과 Melatonin의 작용
약학회지
2005 .01
-
Quinone계 화합물의 발암성 조기검색법에 관한 연구 ( A Short Term Screening Method for Carcinogenic Quinone Compounds )
한국독성학회지
1992 .12
-
Induction of Quinone Reductase by Obtusafuran from Dalbergiae Lignum
대한약학회 학술대회
2003 .01
-
Griseusin C, a Novel Quinone Derivative from a Marine-Derived Fungus Penicillium sp.
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Design and Synthesis of N-Aryl 8,9-Dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-dione Derivatives as Potential Antitumor Agent
대한약학회 학술대회
2003 .01
-
생체 발성모형에서 발성시 공기양의 변화가 음성 지표에 미치는 영향
대한후두음성언어의학회지
1994 .01
-
다채널 음성분석장치를 이용한 정상 성인에서의 발성 방식에 따른 음성변수 분석
대한후두음성언어의학회지
2002 .01
-
Vasorelaxation and Antiproliferation of Apigenin
대한약학회 학술대회
2000 .01
-
Roles of Oxidative Stress in the Development and Progression of Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Quinones ( Menadione , Benzoquinone , 및 2 , 3 - Dimethoxy - 1 , 4 - naphthoquinone ) 의 혈소판 세포독성 ( Effects of Various Quinones ( Menadione , Benzoquinone and 2 , 3-Dimethoxy-1 , 4-naphthoquinone ) on Rat Platelets )
한국독성학회지
1996 .06
-
Evaluation of induction of quinone reductase activity by natural products in cultured murine hepatoma cells
대한약학회 학술대회
2000 .01
-
Enhanced Vasorelaxation of BanhabackchulChunma-tang-1 and Involved Mechanism
대한동의생리학회 학술대회
2005 .01
-
5,8-QUINAZOLINEDIONES AS POTENT INHIBITORS OF ENDOTHELIUM-DEPENDENT VASORELAXATION
대한약학회 학술대회
2000 .01
-
복분자(覆盆子)의 내피세포의존성 혈관이완효과
동의생리병리학회지
2013 .01
-
Anti-aggregation of platelets by quinones is associated with their cytotoxicity to platelets
한국보건교육건강증진학회 학술대회 발표논문집
1999 .10
-
쇄양(鎖陽)의 내피세포 의존성 혈관이완효과
대한본초학회지(본초분과학회지)
2015 .01
-
감두탕 약침액의 암예방 효과에 관한 연구
대한침구의학회지
2000 .01
-
1. Oxidative Stress and Male Infertility: Factor Fiction?;2. Understanding the Role of Oxidative Stress in Human Reproduction
대한생식의학회 학술대회
2000 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0