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논문 기본 정보

자료유형
학술저널
저자정보
윤관하 (울산대학교 의과대학 서울중앙병원 진단방사선과, 아산생명과학연구소 자기공명연구실)
저널정보
대한영상의학회 대한방사선의학회지 대한방사선의학회지 제39권 제6호
발행연도
1998.1
수록면
1,171 - 1,176 (6page)

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Purpose : To assess the spectral alteration of phosphorus metabolities in patients with liver cirrhosis andcompare energy metabolites with clinical grades using 31P MR spectra localized by two-dimensional chemical shiftimaging. Materials and Methods : In 15 normal (control) subjects and 12 patients with liver cirrhosis, 31P MRspectroscopy was undertaken. Patients were divided into two groups, namely 'mild cirrhosis' (Child A, n=5) and'severe cirrhosis' (Child B and C, n=7) according to disease severity, as assessed by Child-Hugh's classification.In vivo 31P MR spectroscopy was performed on a 1.5-T system (Magnetom Vision; Erlangen, Germany), using a surfacecoil. Peak areas of phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), and ${\gamma}$-, $\alpha$- and$\beta$-ATP were defined. Peak areas of phosphorous metabolites in the spectra were expressed as values of PME/$\beta$-ATP,PDE/$\beta$-ATP, PME/ATP, and PME/PDE. Results : The values of PME/$\beta$-ATP, PDE/$\beta$-ATP, PME/ATP, and PME/PDE betweencontrol subjects and patients with liver cirrhosis were significantly different. With impaired hepaticdysfunction, PME increased as PDE decreased. In patients with severe cirrhosis, the values of PME/(-ATP andPME/ATP were significantly higher than those of patients with mild cirrhosis. Conclusion : In patients with livercirrhosis, peak areas of PME, were significantly higher, and this might reflect the severity of hepaticdysfunction. PME/(-ATP and PME/ATP valves appear predict the severity of cirrhosis.

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