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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 대한약학회 대한약학회 학술대회 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- 발행연도
- 2003.1
- 수록면
- 2,311 - 2,311 (1page)
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초록· 키워드
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Mucoadhesive microsphere was prepared by interpo]ymer complexation of po]y(acrylic acid) (PAA) with po]y(vinyl pyrrolidone) (PVP) using solvent diffusion method. The loading efficiency of acetaminophen into the microsphere was 91.3 ${\pm}$ 6.5%. The release rate of acetaminophen from the PAA/PVP complex microspheres was slower than that from PVP microspheres at pH 2.0 and 6.8. The dissolution of microspheres made of the complex was significantly slower than those made of PVP due to H-bond between PVP and PAA. As a result, the release rate of acetaminophen from the complex microspheres was slower than that from PVP microspheres.
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