Effects of the Administration of 5-aryl-2,3-dihydroimidazol [2,1-a] isoquinolines (SDZ-62434) on Kidney

Yi, E.Y.; Ma, Y.; Choi, W.J.; Park, J.S.; Cheon, S.H.; Lim, D.K.

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자료유형: 학술대회자료

저자정보: Yi, E.Y. (College of Pharmacy, Chonnam National University) Ma, Y. (College of Pharmacy, Chonnam National University) Choi, W.J. (College of Pharmacy, Chonnam National University) Park, J.S. (College of Pharmacy, Chonnam National University) Cheon, S.H. (College of Pharmacy, Chonnam National University) Lim, D.K. (College of Pharmacy, Chonnam National University)

저널정보: 한국응용약물학회 한국응용약물학회 춘계학술발표논문집 한국응용약물학회 1996년도 춘계학술대회

발행연도: 1996.1

수록면: 213 - 213 (1page)

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The effects of the anti-tumor agent, SDZ-y2434, on rat kidney were investigated to predict the toxicities of its derivatives and to develope less toxic derivatives. After adjusted in metabolic cages for 5 days, rats were treated SDZ-62434(acute : 25mg/kg, i.p, once and 50mg/kg, i.p., once; subacute ; 10mg/kg, i.p., daily for 7 days). Kidney weights and urine volume during the treatment were observed. Creatinine concentration, protein concentration and the activities of N-acetyl-${\beta}$-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), ${\gamma}$-glutamyl transpeptidase (GGT) and lactate dehydrogenase(LDH) in 24 hr urine were also determined. The kidney weights after the acute and subacute administration didn't show any difference. Urine volume increased 5 days after the acute administration (50mg/kg) and 3 days after the subacute administration. The excretion of creatinine was increased 5 days after the acute (50mg/kg) and subacute administration. However, the protein excretion didn't show any change. NAG acivity declined 7 days after the subacute administration. AAP and GGT activites increased 3 days after the acute administration (50mg/kg) but, returned to the control value. LDH activity showed continuousely high value after the subacute administration. These results indicates that the acute administration of SDZ-62434 might damage on glomerulus and that the subacute administration might be cytotoxic to kidney cells.

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