지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 1996.1
- 수록면
- 284 - 284 (1page)
이용수
초록· 키워드
오류제보하기
Titrated Extract of Centella asiatica (TECA) is a poorly water-soluble extract from the Centella asiatica. Despite excellent wound preparation causes pain due to a low aqueous solubility and high hypertonicity and therefore, the patient's compliance of this drug is low. The objective of this study is to design a formulation of TECA with an improved therapeutic applicability via an adequate solubilization. A mixture of propylene glycol and ethoxylated hydrogenated caster oil achieved an acceptable solubilization of TECA (i.e. 10%) via a formulation of micelle. A preparation of extemporaneous TECA micelle was achieved by a dilution of the original micellar formulation with either water or saline. An estimated distribution of particle size was between 15.9 and 32.6 ㎜. The osmotic pressure of the formulation was found to be much lower than that found In a commercially available injectable (i.e. Madecassole). The erthrocytic hemolysis of micellar solution was lower than that with the conventional dosage form, consistent with the osmotic pressure data. Pain score after an injection of the micellar solution was assessed by the hind-paw writhing test using ICR mice and compared with that found with the conventional injectable. The data indicated that the injection of the micellar solution was a significantly less painful. These results indicated that a micellar solubilization, followed by an extemporaneous dilution, is a novel formulation of TECA with an improved therapeutic applicability.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
비이온성 미셀용액과 수중유형 마이크로에멀젼계의 특성 및 수단 IV의 가용화
약학회지
1995 .01
-
Mixed Micellar Nanoparticle of Amphotericin B and Poly Styreneblock-poly Ethylene Oxide Reduces Nephrotoxicity but Retains Antifungal Activity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Studies of Solubilized Micellar Solutions
대한화장품학회지
1974 .01
-
Development of New Reverse Micellar Microencapsulation Technique to Load Water-Soluble Drug into PLGA Microspheres
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Behavior of Itraconazole and Benzyl Alcohol in Aqueous Solution Containing Nonionic Surfactants
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Tissue Distribution of Novel Polymeric Micellar Paclitaxel in Mice
대한약학회 학술대회
2002 .01
-
Micellar Solubilization of Cholesterol, Cholesteryl Myristate and Gallstones by Synthetic Surfactants
약학회지
1977 .01
-
Comparative In Vitro Toxicity Study of Docetaxel and Nanoxel, a Docetaxel-Loaded Micellar Formulation Using Cultured and Blood Cells
Toxicological Research
2019 .04
-
계면활성제/1-Hoxanol/물 혼합물의 상태도와 전기 전도도에 관한 연구
대한화장품학회지
1986 .01
-
Advanced Formulation and Pharmacological Activity of Hydrogel of the Titrated Extract of C. Asiatica
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Practical approaches on the long‑acting injections
Journal of Pharmaceutical Investigation
2020 .01
-
Fluorescence probe study on the solubilization sites of aniline derivatives in triton X-100 and zephiramine micelles
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1986 .01
-
Preparation and Evaluation of Titrated Extract of Centella Asiatica Niosome/W/O system cream for site-specific targeting
대한약학회 학술대회
2000 .01
-
26. PRESENT STATUS OF THE PROPRIETY OF JUDGEMENT FOR MIXTURE OF INJECTABLE SOLUTION IN OUR HOSPITAL : According to the use of "The scale for the Prompt Judgement of the Propriety of Injection Mixtures
농촌의학·지역보건
1985 .09
-
인도메타신의 용해도에 미치는 계면 활성제의 영향
약학회지
1984 .01
-
모세관 전기영동법을 이용한 제제중의 수용성 비타민 분석
약학회지
1994 .01
-
Injectable Polyphosphazene gels for the Local Drug Delivery
대한약학회 학술대회
2005 .01
-
한약복합물 HT008이 흰쥐 관절염 모델에 미치는 효과
대한본초학회지(본초분과학회지)
2009 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0