The potential impact of low dose ionizing ${gamma}$-radiation on immune response activity up-regulated by Ikaros in IM-9 B lymphocytes

Kim, Sung-Jin; Jang, Seon-A; Yang, Kwang-Hee; Kim, Ji-Young; Kim, Cha-Soon; Nam, Seon-Young; Jeong, Mee-Seon; Jin, Young-Woo

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자료유형: 학술대회자료

저자정보: Kim, Sung-Jin (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) Jang, Seon-A (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) Yang, Kwang-Hee (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) Kim, Ji-Young (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) Kim, Cha-Soon (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) Nam, Seon-Young (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) Jeong, Mee-Seon (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) Jin, Young-Woo (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.)

저널정보: 대한방사선방어학회 대한방사선방어학회 학술발표회 대한방사선방어학회 2011년도 추계 학술발표회 및 심포지엄

발행연도: 2011.1

수록면: 212 - 213 (2page)

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The biological effects of low dose ionizing radiation (LDIR) remain insufficiently understood. We examined for the scientific evidence to show the biological effects of LDIR using radiation-sensitive immune cells. We found that Ikaros protein was responsed to low dose-dependent effects of gamma radiation in IM-9 B lymphocytes. Ikaros encodes zinc finger transcription factors that is important regulators of a hematopoietic stem cells (HSCs) progression to the B lymphoid lineage development, differentiation and proliferation. In this study, we observed that cell proliferation was enhanced from 10% to 20% by LDIR (0.05 Gy) in IM-9 B lymphocytes. The Ikaros protein was phosphorylated in its serine/threonine (S/T) region and decreased its DNA binding activity in the cells exposed to LDIR. We found that Ikaros phosphorylation was up-regulated by CK2/AKT pathway and the residues of ser-304 and ser-306 in Ikaros was phosphorylated by LDIR. We also observed that Ikaros protein was localized from the nucleus to the cytoplasm after LDIR and bound with Autotaxin (ENPP2, ATX) protein, stimulating proliferation, migration and survival of immune cells. In addition, we found that the lysoPLD activity of ATX was dependent on Ikaros-ATX binding activity. These results indicate that the Ikaros is an important regulator of immune activation. Therefore, we suggest that low dose ionizing radiation can be considered as a beneficial effects, stimulating the activation of immune cells.

#Low dose ionizing radiation #LDIR) #Ikaros #Autotaxin #ATX) #Immune activation #Lysophosphatidylcholine #LPC) #Lysophosphatidic acid #LPA)

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