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논문 기본 정보

자료유형
학술대회자료
저자정보
Phuong, Nguyen Thi (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) Min, Young-Ki (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) Yang, Hun-Mo (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) Song, Ho-Yeon (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University) Lee, Byong-Teak (Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University)
저널정보
한국재료학회 한국재료학회 학술발표대회 한국재료학회 2010년도 춘계학술발표대회
발행연도
2010.1
수록면
402 - 402 (1page)

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In this study, oxidized alginate/gelatin/biphase calcium phosphate (BCP)- based hydrogel composites were fabricated. Alginate sodium was oxidized by periodate. The oxidized product was confirmed by using $^1H$ and $^{13}C$ NMR spectra. The number average molecular weight ($M_n$), the average molecular weight ($M_w$) of the oxidized alginate were determined by Gel Permeation Chromatography (GPC). The hydrogel was formed from the oxidized alginate and gelatin solution via Schift-base reaction. The hydrogel showed a highly porosity by a Scanning Electron Microscope (SEM) and Mercury Intrusion Porosimetry (MIP). Crosslinked density of the gel matrix were assessd by trinitrobenzene sulfonic acid (TNBS) assay that shows a high effect on swelling ratio. Increment of the crosslinked desity resulted in enhancing compressive strength of the hydrogel composite. The cytotoxity of hydrogel was assessed with osteoblast MG-63. The hydrogel composites show a high compatibility. The obtained results showed a potential application for bone regeneration in future.

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