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논문 기본 정보

자료유형
학술대회자료
저자정보
Jyoti, Md. Anirban (Dept. of Immunology, Soonchunhyang University) Min, Young-Ki (Dept. of Physiology, Soonchunhyang University) Lee, Byong-Taek (Department of Biomedical Engineering, Soonchunhyang University) Song, Ho-Yeon (Dept. of Immunology, Soonchunhyang University)
저널정보
한국재료학회 한국재료학회 학술발표대회 한국재료학회 2009년도 추계학술발표대회
발행연도
2009.1
수록면
421 - 421 (1page)

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In recent years, it has been tried to develop the efficacy and bioactivity of Calcium Phosphate cements(CPC) as injectable bone substitute (IBS) by reinforcing them through varying the amount in its compositions and relative concentrations or adding other additives. In this study, the biocompatibility of are inforced Calcium Phosphate-Calcium Sulfate injectable bone substitute (IBS)containing poly ($\varepsilon$-caprolactone)PCL microspheres was evaluated which consisted of solution chitosan and Na-citrate as liquid phase and tetra calcium phosphate (TTCP), dicalciumphosphate anhydrous (DCPA) powder as the solid phase. The in vitrobiocompatibility of the IBS was done using MTT assay and Cellular adhesion and spreading studies. The in vitro experiments with simulated body fluid (SBF) confirmed the formation of apatite on sample surface after 7 and 14 days of incubation in SBF. SEM images for one cell morphologies showed that the cellular attachment was good. MG-63 cells were found to maintain their phenotype on samples and SEM micrograph confirmed that cellular attachment was well. In vitro cytotoxicity tests by an extract dilution method showed that the IBS was cytocompatible for fibroblast L-929.

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