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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 한국응용약물학회 한국응용약물학회 추계학술발표논문집 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
- 발행연도
- 2003.1
- 수록면
- 107 - 107 (1page)
이용수
이 논문의 연구 히스토리 (4)
2003
In vivo evidence for brain-to-blood efflux transport of taurine and regulation of this transport by tumor necrosis factor-$\alpha$ at the blood-brain barrier
Lee
,
Na-Young
,
Kang
외 1명
대한약학회 학술대회
2003.01
학술대회자료
Brain-to-blood efflux transport of taurine at the blood-brain barrier in rats
Lee
,
Na-Young
,
Kang
외 1명
대한약학회 학술대회
2003.01
학술대회자료
Choline and basic amine drugs efflux from brain to blood across the blood-brain barrier
Lee
,
Na-Young
,
Kang
외 1명
한국응용약물학회 추계학술발표논문집
2003.01
학술대회자료
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초록· 키워드
오류제보하기
The purpose of this study is to examine that the efflux transport system for choline from brain to blood is present at the blood-brain barrier (BBB) using brain efflux index (BEI) method. ［$^3$H］Choline was microinjected into parietal cortex area 2 (Par2) region of rat brain, and was eliminated from the brain with an apparent elimination half life of 45 min. The BBB efflux clearance of ［$^3$H］choline was 0.12 $m\ell$/min/g brain, which was calculated from the efflux rate constant (1.5${\times}$10$\^$-2/ min$\^$-1/) and the distribution volume in the brain slice (8.1 $m\ell$/g brain). This process was saturable and significantly inhibited by various organic cationic compounds including hemicholinium-3, tetraethylammonium chloride (TEA) and verapamil, by antioxidant, ${\alpha}$-phenyl-n-tert-butyl nitrone (PBN), and by Alzheimer's disease therapeutics, such as acetyl $\ell$-carnitine and tacrine. In conclusion, this finding is the first direct in vivo evidence that choline is transported from brain to the blood across the BBB via a carrier-mediated efflux transport process.
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