지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 225 - 231 (7page)
이용수
이 논문의 연구 히스토리 (3)
2003
Comparative Molecular Similarity Indices Analysis (CoMSIA) on the Melanogenesis Inhibitory Activities of Alkyl-3,4-dihydroxy- benzoate and N-alkyl-3,4-dihydroxybenzamide Derivatives.
Kim
,
Sang-Jin
,
Sung
외 3명
대한화장품학회 학술대회
2003.01
학술대회자료
Comparative Molecular Field Analyses (CoMFA) on the Mela-nogenesis Inhibitory Activities of Alkyl-3,4-dihydroxybenzoyl Derivatives.
Kim
,
Sang-Jin
,
Sung
외 3명
대한화장품학회 학술대회
2003.01
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
To search and development a new material with superior melanogenesis inhibitory activity, the bioactivities (obs. pl$_{50}$) of alkyl-3,4-dihydroxybenzoyl esters and N-alkyl-3,4-dihydroxybenz-oyl amides as substrate molecules were measured in mouse melanoma cells. And also, we have studied that 3-D QSARs (3 dimensional Quantitative Structure-Activity Relationships) between molecular interaction field of substrates and the bioactivities were analyzed using CoMFA (Comparative Molecular Field Analyses) method. When cross-validation value (q$^2$) is 0.68 at 3 components, the Pearson correlation coefficient ($r^2$) is 0.900. From the basis on the findings, the model was appeared by the contour map such as steric field and electrostatic field relationships between quantitative structure and the bioactivity of the various substrate derivatives. Measured bioactivities (obs. pl$_{50}$) of unknown compounds are very similar to predicted activity (pred. pl$_{50}$) according to the CoMFA model. As the results of prediction, we could conclude that the bioactivities were increased by creation of R$_1$ substitution of 5,5-dime-thylhexoxy, 6,6-dimethylheptyl, 1-amino-6,6-dimethylheptyl group etc and R$_2$ substitution of hydroxy, methyl, methoxy group etc.p etc.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
CoMFA on the Melanogenesis Inhibitory Activity of Alkyl-3,4-dihydroxybenzoate, N-Alkyl-3,4-dihydroxybenzamide Analogues, and Prediction of Higher Active Compounds
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Comparative Molecular Field Analysis (CoMFA) of Ceramide Derivatives
대한약학회 학술대회
2000 .01
-
The 3D-QSAR Studies on the Indolinones Derivatives of PTKIs: CoMFA& CoMSIA
대한약학회 학술대회
2003 .01
-
3D-QSAR and docking studies of selective COX-2 inhibitors
대한약학회 학술대회
2003 .01
-
Comparative Molecular Field Analysis of Dioxins and Dioxin-like Compounds
Molecular & cellular toxicology
2005 .01
-
CoMFA and CoMSIA 3D QSAR Studies on Pimarane Cyclooxygenase-2 (COX-2) Inhibitors
대한약학회 학술대회
2003 .01
-
$3{\beta}$-Hydroxy-12-oleanen-28-oic Acid 유도체들의 PTP-1B 저해활성에 대한 CoMFA 분석과 활성 분자들의 예측
대한화장품학회지
2008 .01
-
Comparative Molecular Field Analysis (CoMFA) Study of Antitumor 3-Arylisoquinolines
대한약학회 학술대회
2000 .01
-
Topomer-CoMFA Study of Tricyclic Azepine Derivatives-EGFR Inhibitors
Molecular & cellular toxicology
2008 .01
-
CoMFA법을 이용한 3-아릴이소퀴놀린 화합물들의 SK-OV-3 암세포에 대한 가상의 약물 작용 수용체 해석
약학회지
2002 .01
-
The 3-D QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and COMSIA
대한약학회 학술대회
2002 .01
-
CoMFA of 1-phenyl-2-substituted thioureas for their cytotoxicity
대한약학회 학술대회
2002 .01
-
Molecular modeling of COX-2 inhibitors: 3D-QSAR and docking studies
대한약학회 학술대회
2003 .01
-
CoMFA Based Quantitative Structure Toxicity Relationship of Azo Dyes
Molecular & cellular toxicology
2007 .01
-
Comparative Molecular Similarity Indices Analysis (CoMSIA) on the Melanogenesis Inhibitory Activities of Alkyl-3,4-dihydroxy- benzoate and N-alkyl-3,4-dihydroxybenzamide Derivatives.
대한화장품학회 학술대회
2003 .01
-
CoMFA analysis of 2-phenyl-1,8-naphthyridin-4-ones for cytotoxicity
대한약학회 학술대회
2001 .01
-
Prediction on the Chiral Behaviors of Drugs with Amine Moiety on the Chiral Cellobiohydrolase Stationary Phase Using a Partial Least Square Method
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
3-D QSAR Studies on Thiazole and Triazole Antifungal Agents by CoMFA and CoMSIA
대한약학회 학술대회
2003 .01
-
CoMFA analysis of N-acyl-phenylaminoalcohols for cytotoxicity
대한약학회 학술대회
2000 .01
-
3D-QSAR (CoMFA, CoMSIA) study of PPAR-$\gamma$ agonists.
대한약학회 학술대회
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0