지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 51 - 57 (7page)
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초록· 키워드
오류제보하기
Background and ObjectivesFor experiments on simulated burn, the preparation of an animal model is a very important step. The purpose of the current experiment is to design a simple and controllable method for the preparation of third-degree scald in a mouse model using the boiling water method. Materials and MethodsA total of 18 Swiss mice were used. After the anesthetization, the mice were scalded by boiling water (100°C) using a mold with a 1 cm2 circle area on the dorsum at contact times of 3s, 5s, and 8s. After confirming that 8 seconds of scald can cause a third-degree scald, the skin samples were collected at day 2, 4, 6, 8, 10, and 12, and analyzed by histopathological examinations. The wound retraction index (WRI) was also measured. ResultsThird-degree scald involving full-thickness skin was observed in the 8-second scald group, while a 3-second scald caused a superficial second-degree scald and a 5-second scald caused a deep second-degree scald. After third-degree scald, the burn wound continued to contract until day 14. ConclusionThe scalding model of mice can be successfully established by the boiling water method. This method is easy to operate, it has a low cost, and it can control the scald depth by controlling the scald time. This is adequate to study skin thermal injury in the future. The scald model established by this method can last for 14 days.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Toussaint J / 2014 / The evaluation and management of thermal injuries : 2014 update / Clin Exp Emerg Med 1:8~18
Bessey PQ / 2014 / Synopsis of the 2013 annual report of the national burn repository / J Burn Care Res 35(Suppl 2):S218~S234
Lee SJ / 2015 / Treatment of burn scars with the pinhole 4. 0 method using a 10, 600-nm carbon dioxide laser / Med Laser 4:70~73
Hae-Jin Lee / 2019 / Burn Wound Successfully Treated with 830-nm Light Emitting Diode Phototherapy Combined with Epidermal Growth Factor Solution / MEDICAL LASERS 8(2):94~96
Wang Seok Lee / 2018 / Successful Treatment of Recalcitrant Remaining Postoperative Wounds by Dual-Frequency Ultrasound / MEDICAL LASERS 7(2):74~78
Bessey PQ / 2014 / Synopsis of the 2013 annual report of the national burn repository / J Burn Care Res 35(Suppl 2):S218~S234
Lee SJ / 2015 / Treatment of burn scars with the pinhole 4. 0 method using a 10, 600-nm carbon dioxide laser / Med Laser 4:70~73
Hae-Jin Lee / 2019 / Burn Wound Successfully Treated with 830-nm Light Emitting Diode Phototherapy Combined with Epidermal Growth Factor Solution / MEDICAL LASERS 8(2):94~96
Wang Seok Lee / 2018 / Successful Treatment of Recalcitrant Remaining Postoperative Wounds by Dual-Frequency Ultrasound / MEDICAL LASERS 7(2):74~78
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