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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 19 - 29 (11page)
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초록· 키워드
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Background and Objectives: Perfluoroalkyl substances (PFASs) are known to disrupt the thyroid hormone system. However, no study has assessed the association between multiple exposure to PFASs and the thyroid hormone system. This study aimed to identify the singular effects of each PFAS and the effects of multiple exposure to PFASs on the thyroid hormone profile in a representative sample of the US population. Materials and Methods: We used data from the US National Health and Nutrition Examination Survey (NHANES) 2007-2008 and 2011-2012. To assess the effect of simultaneous exposure to multiple PFASs on thyroid function, principal component (PC) analysis with varimax rotation was performed. Multivariate linear regression analysis was conducted to identify the effect of each PFAS and PC on thyroid function. Results: In this study, perfluorooctanoate (PFOA) was associated with a decrease in total T4 and Free T4 levels. Perfluorooctane sulfonate (PFOS) was associated with a decrease in total T4 level and perfluorononanoate (PFNA) and perfluorodecanoate (PFDeA) were associated with decreases in TSH levels. In PC analysis, two PCs were identified. PC1 included PFOA, PFOS, perfluorohexane sulfonate (PFHxS), PFNA and 2-(N-methyl-perfluorooctane sulfonamido) acetic acid with high loading. PC2 included PFNA, PFDeA, and perfluoroundecanoate (PFUA). In the multivariate linear regression analysis, PC1 showed negative correlations with total T4 and Free T4 levels, whereas PC2 showed a negative correlation with TSH level. Conclusion: We found that singular and multiple exposure to PFASs was associated with a disruption in thyroid hormone system.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Fromme H / 2009 / Perfluorinated compounds--exposure assessment for the general population in Western countries / Int J Hyg Environ Health 212(3):239~270
Calafat AM / 2007 / Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES)2003-2004 and comparisons with NHANES 1999-2000 / Environ Health Perspect 115(11):1596~1602
U.S. Environmental Protection Agency / 2005 / Draft risk assessment of the potential human health effects associated with exposure to perflouroctanoic acids and its salts / U.S. Environmental Protection Agency
Grandjean P / 2015 / Perfluorinated alkyl substances : emerging insights into health risks / New Solut 25(2):147~163
Bach CC / 2015 / Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth : a systematic review / Crit Rev Toxicol 45(1):53~67
Calafat AM / 2007 / Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES)2003-2004 and comparisons with NHANES 1999-2000 / Environ Health Perspect 115(11):1596~1602
U.S. Environmental Protection Agency / 2005 / Draft risk assessment of the potential human health effects associated with exposure to perflouroctanoic acids and its salts / U.S. Environmental Protection Agency
Grandjean P / 2015 / Perfluorinated alkyl substances : emerging insights into health risks / New Solut 25(2):147~163
Bach CC / 2015 / Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth : a systematic review / Crit Rev Toxicol 45(1):53~67
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