지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 492 - 499 (8page)
이용수
초록· 키워드
오류제보하기
Background/Aims: The pathogenesis of nonalcoholic fatty liver disease (NAFLD) has not be fully elucidated, and the lack of therapeutic strategies for NAFLD is an urgent health problem. Guanine nucleotide binding protein, alpha inhibiting activity polypeptide 3 (GNAI3) participates in several biological processes, but its relationship with lipid metabolism and NAFLD has not yet been reported. We aimed to determine the function of GNAI3 in the development of NAFLD. Methods: Mice were fed a methionine and choline-deficient diet to induce NAFLD. An NAFLD model in HepG2 cells was induced by free fatty acid treatment. GNAI3 levels in HepG2 cells were downregulated by shRNA. Protein levels of related proteins were evaluated by Western blotting, and mRNA levels were determined by quantitative reverse transcription polymerase chain reaction. Hematoxylin and eosin and Oil Red O staining were used to observe histological changes in liver tissue. Results: The dysregulated hepatic lipid metabolism in the NAFLD mouse model was enhanced by GNAI3 knockout, which also provoked worse liver damage. In the NAFLD model in HepG2 cells, the downregulation of GNAI3 promoted cellular lipid accumulation and enhanced the changes in lipid metabolic enzyme levels. Conclusions: This study demonstrates that GNAI3 participates in the development of NAFLD in both cellular and mouse models. The data indicate that GNAI3 is a potential new target for the treatment of NAFLD in humans.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Watanabe S / 2015 / Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis / Hepatol Res 45:363~377
Nascimbeni F / 2013 / From NAFLD in clinical practice to answers from guidelines / J Hepatol 59:859~871
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:73~84
Lonardo A / 2016 / Global epidemiology of nonalcoholic fatty liver disease : meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:1388~1389
Li Z / 2014 / Prevalence of nonalcoholic fatty liver disease in mainland of China : a meta-analysis of published studies / J Gastroenterol Hepatol 29:42~51
Nascimbeni F / 2013 / From NAFLD in clinical practice to answers from guidelines / J Hepatol 59:859~871
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:73~84
Lonardo A / 2016 / Global epidemiology of nonalcoholic fatty liver disease : meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:1388~1389
Li Z / 2014 / Prevalence of nonalcoholic fatty liver disease in mainland of China : a meta-analysis of published studies / J Gastroenterol Hepatol 29:42~51
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Recent Epidemiology and Risk Factors of Nonalcoholic Fatty Liver Disease
Journal of Obesity & Metabolic Syndrome
2022 .03
-
Improvement of Nonalcoholic Fatty Liver Disease Reduces the Risk of Type 2 Diabetes Mellitus
Gut and Liver
2019 .01
-
Risk factors in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .02
-
Nonalcoholic fatty liver disease and non-liver comorbidities
Clinical and Molecular Hepatology
2023 .02
-
Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment
Diabetes and Metabolism Journal
2019 .01
-
A Nomogram for Predicting Non-Alcoholic Fatty Liver Disease in Obese Children
Pediatric Gastroenterology, Hepatology & Nutrition
2020 .01
-
Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .02
-
Non-Laboratory-Based Simple Screening Model for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Developed Using Multi-Center Cohorts
Endocrinology and Metabolism
2021 .08
-
Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population
Gut and Liver
2018 .01
-
Characteristic Features of Nonalcoholic Fatty Liver Disease in Japan with a Focus on the Roles of Age, Sex and Body Mass Index
Gut and Liver
2020 .01
-
Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
Diabetes and Metabolism Journal
2019 .01
-
Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2020 .01
-
The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study
Gut and Liver
2024 .07
-
Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease
Endocrinology and Metabolism
2016 .01
-
Nonalcoholic Fatty Liver Disease Is Associated with Benign Prostate Hyperplasia
Journal of Korean Medical Science
2020 .01
-
The effect of diabetes and prediabetes on the prevalence, complications and mortality in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2022 .07
-
비알코올성 지방간 질환과 소포체 스트레스
대한내과학회지
2021 .04
-
Interaction between sarcopenia and nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .02
-
비알코올성지방간의 유관 인자 임상 연구: 종양표지자, 심박변이도, 사상체질
JSCM : Journal of Sasang constitutional medicine
2019 .01
-
Altered fuel metabolism in the pathogenesis of NAFLD
한국실험동물학회 학술발표대회 논문집
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0