지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 459 - 467 (9page)
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초록· 키워드
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Background/Aims: Limited data are available regarding psychosocial distress at the time of diagnosis of ulcerative colitis (UC). We investigated the psychosocial burden and factors related to poor health-related quality of life (HRQL) among patients newly diagnosed with moderate-to-severe UC who were affiliated with the nationwide prospective cohort study. Methods: Within the first 4 weeks of UC diagnosis, all patients were assessed using the Hospital Anxiety and Depression Scale (HADS), Work Productivity and Activity Impairment questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ), and 12-Item Short Form (SF-12) health survey. A multiple linear regression model was used to identify factors associated with HRQL. Results: Between August 2014 and February 2017, 355 patients completed questionnaires. Significant mood disorders requiring psychological interventions, defined by a HADS score ≥11, were identified in 16.7% (anxiety) and 20.6% (depression) of patients. Patients with severe disease were more likely to have presenteeism, loss of work productivity, and activity loss than those with moderate disease (all p<0.05). Significant mood disorders had the strongest negative relationship with total IBDQ score, which indicates disease-specific HRQL (β coefficient: –22.1 for depression and –40.0 for anxiety, p<0.001). The scores of all SF-12 dimensions, which indicate general HRQL, were remarkably decreased in the study population compared indirectly with previously reported scores in the general population. The Mayo score, C-reactive protein level, and white blood cell count showed significant negative associations with the IBDQ score (p<0.05). Conclusions: Psychosocial screening and timely interventions should be incorporated into the initial care of patients newly diagnosed with UC.
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등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Irvine EJ / 2008 / Quality of life of patients with ulcerative colitis : past, present, and future / Inflamm Bowel Dis 14:554~565
Yarlas A / 2018 / Burden of ulcerative colitis on functioning and well-being : a systematic literature review of the SF-36® health survey / J Crohns Colitis 12:600~609
Williet N / 2014 / Patient-reported outcomes as primary end points in clinical trials of inflammatory bowel disease / Clin Gastroenterol Hepatol 12:1246~1256
Feagan BG / 2017 / Effects of vedolizumab on health-related quality of life in patients with ulcerative colitis : results from the randomised GEMINI 1 trial / Aliment Pharmacol Ther 45:264~275
Han SW / 2005 / Predictors of quality of life in ulcerative colitis : the importance of symptoms and illness representations / Inflamm Bowel Dis 11:24~34
Yarlas A / 2018 / Burden of ulcerative colitis on functioning and well-being : a systematic literature review of the SF-36® health survey / J Crohns Colitis 12:600~609
Williet N / 2014 / Patient-reported outcomes as primary end points in clinical trials of inflammatory bowel disease / Clin Gastroenterol Hepatol 12:1246~1256
Feagan BG / 2017 / Effects of vedolizumab on health-related quality of life in patients with ulcerative colitis : results from the randomised GEMINI 1 trial / Aliment Pharmacol Ther 45:264~275
Han SW / 2005 / Predictors of quality of life in ulcerative colitis : the importance of symptoms and illness representations / Inflamm Bowel Dis 11:24~34
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