Multicenter Retrospective Analysis of Intraperitoneal Paclitaxel and Systemic Chemotherapy for Advanced Gastric Cancer with Peritoneal Metastasis

김동욱; Ye Seob Jee; Chang Hyun Kim; Jin-Jo Kim; Sungsoo Park; Sung Il Choi; Joong-Min Park; Jong-Han Kim; PIPS-GC

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자료유형: 학술저널

저자정보: 김동욱 Ye Seob Jee Chang Hyun Kim Jin-Jo Kim Sungsoo Park Sung Il Choi Joong-Min Park Jong-Han Kim PIPS-GC

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제20권 제1호

발행연도: 2020.1

수록면: 50 - 59 (10page)

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Purpose The objective of the present retrospective analysis was to describe the experience of intraperitoneal (IP) paclitaxel and systemic chemotherapy in patients with peritoneal metastasis (PM) of advanced gastric cancer (AGC) in a multicenter setting in Korea. Materials and Methods The medical records of patients with AGC, who were diagnosed with PM between January 2015 and December 2018, were reviewed. IP catheter was placed in the pouch of Douglas and was used for the administration of IP paclitaxel chemotherapy. Results We reviewed the clinical outcomes of IP paclitaxel and systemic chemotherapy administration in 82 patients at six institutions in Korea. Mean number of IP chemotherapy cycles was 6.6. The mean peritoneal cancer index (PCI) was 21.9. Postoperative complications related to IP catheter and port were observed in 15 patients. The overall median survival was 20.0 months. A significant difference was observed in the survival rate according to the ascites grade (grade I and II, 24.1 months; grade III and IV, 15.3 months; P=0.014) and PCI grade (grade I, 25.6 months; grade II and III, 16.3 months; P=0.023). Conclusions The feasibility of IP paclitaxel and systemic chemotherapy administration was demonstrated in this experience-based retrospective analysis suggesting that the procedure is beneficial in patients with PM of AGC.

참고문헌 (24)

참고문헌 신청

Lee JH / 2014 / Factors predicting peritoneal recurrence in advanced gastric cancer : implication for adjuvant intraperitoneal chemotherapy / Gastric Cancer 17:529~536

Guideline Committee of the Korean Gastric Cancer Association / 2019 / Korean Practice Guideline for Gastric Cancer 2018; Evidence-based, Multi-disciplinary Approach / Journal of Gastric Cancer 19(1):1~48

Japanese Gastric Cancer Association / 2017 / Japanese gastric cancer treatment guidelines 2014(ver. 4) / Gastric Cancer 20:1~19

Koizumi W / 2008 / S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer(SPIRITS trial) : a phase III trial / Lancet Oncol 9:215~221

Kang YK / 2009 / Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer : a randomised phase III noninferiority trial / Ann Oncol 20:666~673

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