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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 73 - 81 (9page)
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초록· 키워드
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Purpose: To identify factors associated with the clinical response to low-dose dexamethasone therapy (LDDT) in preterm infants for bronchopulmonary dysplasia (BPD). Methods: We used a retrospective medical record review to evaluate preterm infants who were born before 32 weeks of gestation or with a birth weight less than 1,500 g. All infants were admitted to the neonatal intensive care unit at a tertiary academic hospital between January 2010 and June 2019, and received LDDT for BPD. The preterm infants’ respiratory severity scores (RSS) were calculated from the first day of LDDT to the day of extubation, or the last day of LDDT. A good response was defined as a decreasing RSS with a slope greater than 0.181. A poor response was defined as a non-decreasing RSS, or a decreasing RSS with a slope less than 0.181 during LDDT. A total dose of 1.1 mg/kg was administered for 10 days for each single course of LDDT. Results: A total of 51 preterm infants were included in the final analysis. Thirty preterm infants (58.8 %) were in the good response group, and 21 preterm infants (41.2%) were in the poor response group. There were no significant differences in gestational age, birth weight, and sex between the good response group and poor response group. Preterm premature rupture of membrane and histologic chorioamnionitis were significantly associated with a poor response to LDDT. Higher RSS on the first day of the LDDT was associated with a good response to LDDT. Conclusion: Antenatal infection and/or inflammation may be associated with an unfavorable response to postnatal LDDT for BPD. Preterm infants with more severe respiratory failure seem to benefit more from LDDT for BPD.
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참고문헌 (37)
참고문헌 신청
Baraldi E / 2007 / Chronic lung disease after premature birth / N Engl J Med 357:1946~1955
Jo HS / 2015 / Recent changes in the incidence of bronchopulmonary dysplasia among very-lowbirth-weight infants in Korea / J Korean Med Sci 30(Suppl 1):S81~S87
김진규 / 2016 / Trends in Survival and Incidence of Bronchopulmonary Dysplasia in Extremely Preterm Infants at 23-26 Weeks Gestation / Journal of Korean Medical Science 31(3):423~429
Manktelow BN / 2001 / Factors affecting the incidence of chronic lung disease of prematurity in 1987, 1992, and 1997 / Arch Dis Child Fetal Neonatal Ed 85:F33~F35
Stoll BJ / 2015 / Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012 / JAMA 314:1039~1051
Jo HS / 2015 / Recent changes in the incidence of bronchopulmonary dysplasia among very-lowbirth-weight infants in Korea / J Korean Med Sci 30(Suppl 1):S81~S87
김진규 / 2016 / Trends in Survival and Incidence of Bronchopulmonary Dysplasia in Extremely Preterm Infants at 23-26 Weeks Gestation / Journal of Korean Medical Science 31(3):423~429
Manktelow BN / 2001 / Factors affecting the incidence of chronic lung disease of prematurity in 1987, 1992, and 1997 / Arch Dis Child Fetal Neonatal Ed 85:F33~F35
Stoll BJ / 2015 / Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012 / JAMA 314:1039~1051
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