지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 191 - 197 (7page)
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초록· 키워드
오류제보하기
Purpose: Persistent pulmonary hypertension of the newborn (PPHN) is a potentially fatal disease. Inhaled iloprost, a stable analogue of prostacyclin, has recently been used as a therapeutic option. However, there are no clinical guidelines on the use of iloprost, specifically for neonates. This study aimed to suggest the use of inhaled iloprost as a rescue therapy for PPHN based on our experience. Methods: The efficacy and adverse events of inhaled iloprost were evaluated prospectively in nine full-term neonates with PPHN. We monitored the following parameters: fraction of inspired oxygen (FiO2), respiratory severity score (RSS), heart rate, and mean blood pressure. Results: The inhalation dose was 1 to 2 μg/kg initially, and 4 to 8 inhalations per day were applied over 2 to 8 days, except in the case of one neonate who died 2 days after birth. Echocardiographic findings, changes in FiO2, and RSS improved within the next 7 days in eight of the nine patients. Severe side effects on heart rate and blood pressure were not observed. Conclusion: Our experience suggests that inhaled iloprost can be used as a first-line treatment in newborn infants with PPHN when inhaled nitric oxide is not available. To the best of our knowledge, this report is the first prospective case series on the use of inhaled iloprost in PPHN.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Nair J / 2014 / Update on PPHN: mechanisms and treatment / Semin Perinatol 38:78~91
Maxey DM / 2013 / Food and Drug Administration (FDA) postmarket reported side effects and adverse events associated with pulmonary hypertension therapy in pediatric patients / Pediatr Cardiol 34:1628~1636
Ehlen M / 2003 / Iloprost in persistent pulmonary hypertension of the newborn / Cardiol Young 13:361~363
Avila-Alvarez A / 2013 / Inhaled iloprost as a rescue therapy for transposition of the great arteries with persistent pulmonary hypertension of the newborn / Pediatr Cardiol 34:2027~2029
De Luca D / 2007 / Iloprost as ‘rescue’therapy for pulmonary hypertension of the neonate / Paediatr Anaesth 17:394~395
Maxey DM / 2013 / Food and Drug Administration (FDA) postmarket reported side effects and adverse events associated with pulmonary hypertension therapy in pediatric patients / Pediatr Cardiol 34:1628~1636
Ehlen M / 2003 / Iloprost in persistent pulmonary hypertension of the newborn / Cardiol Young 13:361~363
Avila-Alvarez A / 2013 / Inhaled iloprost as a rescue therapy for transposition of the great arteries with persistent pulmonary hypertension of the newborn / Pediatr Cardiol 34:2027~2029
De Luca D / 2007 / Iloprost as ‘rescue’therapy for pulmonary hypertension of the neonate / Paediatr Anaesth 17:394~395
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