지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 291 - 300 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: This study sought to investigate associations among Yonsei criteria (tumor confined to the pancreas, intact fascia layer between the distal pancreas and the left adrenal gland and kidney, and tumor located more than 1–2 cm from the celiac axis) and tumor infiltrating lymphocytes in pancreatic cancer. Materials and Methods: Patients who underwent curative distal pancreatectomy due to left-sided pancreatic cancer from January 2000 to December 2011 were enrolled. Follow-up was completed September 30, 2015. Results: Fifty patients were enrolled. Having ≥ two metastatic lymph nodes (LNs, p=0.002), intraoperative transfusion (p=0.011), low levels of tumor infiltrating CD8+ T-cells (p=0.001), and a high Foxp3+/CD8+ ratio (p=0.009) were independent risk factors for disease-free survival. Not satisfying the Yonsei criteria (p=0.021), having ≥ two metastatic LNs (p=0.032), low levels of tumor infiltrating CD8+ T-cells (p=0.040) and a high Foxp3+/CD8+ ratio (p=0.032) were associated with unfavorable overall survival. High levels of CA19-9 and not satisfying the Yonsei criteria were significantly associated with a high Foxp3+/CD8+ ratio [Exp(β)=3.558; 95% confidence inverval: 1.000–12.658; p=0.050]. Conclusion: Yonsei criteria may be clinically detectable biologic marker with which to predict immunologic status and survival in pancreatic cancer patients.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Hidalgo M / 2010 / Pancreatic cancer / N Engl J Med 362:1605~1617
정윤숙 / 2018 / Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity / Yonsei Medical Journal 59(4):554~562
Bates GJ / 2006 / Quantification of regulatory T cells enables the identification of highrisk breast cancer patients and those at risk of late relapse / J Clin Oncol 24:5373~5380
Fu J / 2007 / Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients / Gastroenterology 132:2328~2339
Kim HI / 2011 / The ratio of intra-tumoral regulatory T cells(Foxp3+)/helper T cells(CD4+)is a prognostic factor and associated with recurrence pattern in gastric cardia cancer / J Surg Oncol 104:728~733
정윤숙 / 2018 / Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity / Yonsei Medical Journal 59(4):554~562
Bates GJ / 2006 / Quantification of regulatory T cells enables the identification of highrisk breast cancer patients and those at risk of late relapse / J Clin Oncol 24:5373~5380
Fu J / 2007 / Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients / Gastroenterology 132:2328~2339
Kim HI / 2011 / The ratio of intra-tumoral regulatory T cells(Foxp3+)/helper T cells(CD4+)is a prognostic factor and associated with recurrence pattern in gastric cardia cancer / J Surg Oncol 104:728~733
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