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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 429 - 439 (11page)
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초록· 키워드
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Purpose: To explore the effects of biodegradable magnesium alloy stents (BMAS) on remodeling of vein graft (VG) anastomoticrestenosis. Materials and Methods: To establish a VG restenosis model, seventy two New Zealand rabbits were randomly divided into threegroups according to whether a stent was implanted in the graft vein or not. BMASs and 316L stainless steel stents were implantedin BMAS and 316L groups, respectively, while no stent was implanted in the no-treatment control group (NC group). Loss of lumendiameter in the graft vein was measured in all three groups. Upon harvesting VG segments to evaluate intimal proliferationand re-endothelization, the degradation and biological safety of the stents were observed to explore the effects of BMAS on VGremodeling. Results: Model establishment and stent implantation were successful. The BMAS reduced lumen loss, compared with the controlgroup (0.05±0.34 mm vs. 0.90±0.39 mm, p=0.001), in the early stage. The neointimal area was smaller in the BMAS group than the316L group after 4 months (4.96±0.66 mm2 vs. 6.80±0.69 mm2, p=0.017). Re-endothelialization in the BMAS group was better thanthat in the 316L group (p=0.001). Within 4 months, the BMAS had degraded, and the magnesium was converted to phosphorusand calcium. The support force of the BMAS began to reduce at 2–3 months after implantation, without significant toxic effects. Conclusion: BMAS promotes positive remodeling of VG anastomosis and has advantages over the conventional 316L stents in thetreatment of venous diseases.
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참고문헌 (26)
참고문헌 신청
Mohr FW / 2013 / Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease : 5-year follow-up of the randomised, clinical SYNTAX trial / Lancet 381:629~638
Habib RH / 2015 / CABG versus PCI : greater benefit in long-term outcomes with multiple arterial bypass grafting / J Am Coll Cardiol 66:1417~1427
Harskamp RE / 2013 / Saphenous vein graft failure after coronary artery bypass surgery : pathophysiology, management, and future directions / AnnSurg 257:824~833
Brennan JM / 2016 / Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals : results from the medicare-linked National Cardiovascular Data Registry(®)CathPCI Registry(®)(2005-2009) / Catheter Cardiovasc Interv 87:43~49
Pokala NR / 2016 / Long-term outcomes with first- vs. secondgeneration drug-eluting stents in saphenous vein graft lesions / Catheter Cardiovasc Interv 87:34~40
Habib RH / 2015 / CABG versus PCI : greater benefit in long-term outcomes with multiple arterial bypass grafting / J Am Coll Cardiol 66:1417~1427
Harskamp RE / 2013 / Saphenous vein graft failure after coronary artery bypass surgery : pathophysiology, management, and future directions / AnnSurg 257:824~833
Brennan JM / 2016 / Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals : results from the medicare-linked National Cardiovascular Data Registry(®)CathPCI Registry(®)(2005-2009) / Catheter Cardiovasc Interv 87:43~49
Pokala NR / 2016 / Long-term outcomes with first- vs. secondgeneration drug-eluting stents in saphenous vein graft lesions / Catheter Cardiovasc Interv 87:34~40
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