Manuka Honey versus Antibiotic Ear Drops in Healing of Post-Operative Mastoid Cavity: A Prospective Randomized Trial

Niveditha Damodharan; Roshan Kumar Verma; Archana Angrup; Naresh K Panda; Naresh K Panda

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자료유형: 학술저널

저자정보: Niveditha Damodharan Roshan Kumar Verma Archana Angrup Naresh K Panda Naresh K Panda

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제63권 제5호

발행연도: 2020.1

수록면: 199 - 205 (7page)

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Background and Objectives This study investigates the role of manuka honey in the healingof postoperative mastoid cavity. Subjects and Method This was a single centre prospective study on 40 consecutive patientsof chronic otitis media undergoing canal wall down mastoidectomy. Manuka honey soaked ingel foam was kept in the mastoid cavity for the study group and antibiotic soaked gel foam waskept for the control group. Culture swabs from mastoid granulations were sent at various timesfrom both groups. The healing of the mastoid cavity was assessed in the follow up period. Results Preoperatively 15 out of 20 patients (75%) had a positive aural swab culture in thestudy group while 11 out of 20 (55%) in the control group had a positive aural swab culture. Themost common organism isolated was Pseudomonas aeruginosa and Proteus mirabilis. Onemonth after mastoidectomy only 4 patients (20%) had sterile culture and 16 patients (80%) hadgrown organisms; in the control group, 7 patients (35%) had sterile culture and 13 patients (65%)had growth on culture. The mean merchant scores for the study group and the control were 2.61(2-5) and 2.05 (1-4), respectively. At 3 months 13 patients (65%) with sterile culture and 7 patients(35%) had growth on culture; in the control group, 16 patients (80%) had sterile cultureand 4 had shown persistent growth on culture (p=0.28). All positive cultures were aerobic inboth groups. The mean merchant scores for the study group and the control were 1.03 (0-4)and 0.7 (0-3), respectively (p=0.09). Conclusion Healing of mastoid cavity was almost similar in both groups (p>0.05). Manukahoney exhibited antibacterial activity against Pseudomonas, Proteus, Klebsiella, Escherichiacoli, Staphylococcus

참고문헌 (15)

참고문헌 신청

Mishra SG / 1990 / Microbial studies of post-operative mastoid cavities / Indian J Otolaryngol Head Neck Surg 42(2):63~65

Albert RR / 2005 / Outcome of bacterial culture from mastoid granulations: Is it relevant in chronic ear disease? / J Laryngol Otol 119(10):774~778

Macfadyen CA / 2006 / Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations / Cochrane Database Syst Rev (1):CD005608

Carlin WV / 1987 / Systemic antibiotic prophylaxis and reconstructive ear surgery / Clin Otolaryngol Allied Sci 12(6):441~446

Saunders JE / 2011 / Antibiotic resistance and otomycosis in the draining ear: Culture results by diagnosis / Am J Otolaryngol 32(6):470~476

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