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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Big data analysis methods are useful tools for sorting valuable data and products. Achyranthes Radix root extract (AR) is a well-known herbal medicine in East Asia due to its anti-osteoarthritis, pro-circulatory, and anti-osteoporosis effects. In this stud y, we investigated the liver- and kidney-protective effects of AR by applying big data analysis to traditional medicine. CDDP (cis-diamminedichloridoplatinum) is an effective cancer cell anti-proliferative agent used in the treatment of diverse types of tumors. However, it is clinically limited due to liver and kidney toxicity. The current study was designed to assess the potential protective effects of AR against CDDP-induced hepato-renal toxicity. For this purpose, male Sprague-Dawley (SD) rats were assigned to four groups, each consisting of four animals. Intravenous injection or oral administration of either saline or AR was performed daily for 14 days, whereas CDDP was injected intraperitoneally on day 3 following AR treatment. Serum biochemistry results revealed that CDDP induced clear hepatic and renal damage while the AR treatment groups showed less damage relative to controls. Next, we tested the pharmacokinetics of AR using 20-hydroxyecdysone (20-HE), which is the most abundant component of AR extract. After intravenous administration of AR, the plasma concentration of 20-HE rapidly declined with a terminal half-life (t1/2) of 0.99±0.47 h. The area under the plasma concentration vs. time curve was 24.96±3.5 h*ng/mL. The present study provides valuable tools for further verification studies of the classical herbal literature and its scientific relevance.
목차
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참고문헌 (29)
참고문헌 신청
Mowrey D / 1986 / Scientific Validation of Herbal Medicine / McGraw-Hill Education
Zhu JS / 1998 / The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I / J Altern Complement Med 4(3):289~303
Folashade O / 2012 / Standardization of herbal medicines-A review / International Journal of Biodiversity and Conservation 4(3):101~112
Garg V / 2012 / Facts about standardization of herbal medicine: a review. Zhong xi yi jie he xue bao / Journal of Chinese integrative medicine 10(10):1077~1083
Kunle / 2012 / Standardization of herbal medicines - A review / International Journal of Biodiversity and Conservation 4(3)
Zhu JS / 1998 / The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I / J Altern Complement Med 4(3):289~303
Folashade O / 2012 / Standardization of herbal medicines-A review / International Journal of Biodiversity and Conservation 4(3):101~112
Garg V / 2012 / Facts about standardization of herbal medicine: a review. Zhong xi yi jie he xue bao / Journal of Chinese integrative medicine 10(10):1077~1083
Kunle / 2012 / Standardization of herbal medicines - A review / International Journal of Biodiversity and Conservation 4(3)
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