지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives Mild cognitive impairment (MCI) patients show decreased semantic memory-processing ability including that for naming objects. We examined event-related potentials (ERPs) associated with the semantic processing of MCI patients and compared their ERPs to those of cognitively normal elderly subjects. Methods A total of 25 MCI patients and 23 age-matched cognitively normal elderly controls (CN) participated in an object-word matching task that consisted of responding to whether a word stimulus matched the picture stimulus preceding it. There were three types of object-name pairs: 1) matched pair, 2) related but mismatched pair, and 3) unrelated mismatched pair. We compared the mean amplitude of ERPs to examine the mismatch effects between matched and mismatched pairs (N400M) and the category effect between inner category and outer category mismatched words (N400C) in CN and MCI patients. Results Compared to the CN subjects, the MCI patients showed a distinct N400M response to mismatch conditions, but the observed range was limited in the centroparietal area. While CN individuals showed a significantly larger N400C amplitude for unrelated mismatch pairs than those for related mismatch pairs, MCI patients exhibited no significant difference between those pair types. Conclusion The MCI showed a lack of the category effects in ERP responses, which may reflect latent behavioral impairments.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Petersen RC / 1999 / Mild cognitive impairment : clinical characterization and outcome / Arch Neurol 56:303~308
Morris JC / 2001 / Mild cognitive impairment represents early-stage Alzheimer disease / Arch Neurol 58:397~405
Tchakoute CT / 2017 / Semantic memory in the clinical progression of Alzheimer disease / Cogn Behav Neurol 30:81~89
Jonker C / 2000 / Are memory complaints predictive for dementia? A review of clinical and population-based studies / Int J Geriatr Psychiatry 15:983~991
Albert MS / 2011 / The diagnosis of mild cognitive impairment due to Alzheimer’s disease : recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease / Alzheimers Dement 7:270~279
Morris JC / 2001 / Mild cognitive impairment represents early-stage Alzheimer disease / Arch Neurol 58:397~405
Tchakoute CT / 2017 / Semantic memory in the clinical progression of Alzheimer disease / Cogn Behav Neurol 30:81~89
Jonker C / 2000 / Are memory complaints predictive for dementia? A review of clinical and population-based studies / Int J Geriatr Psychiatry 15:983~991
Albert MS / 2011 / The diagnosis of mild cognitive impairment due to Alzheimer’s disease : recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease / Alzheimers Dement 7:270~279
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