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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 213 - 220 (8page)
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초록· 키워드
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Background/Aims: The management of small, incidentally discovered nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs)has been a matter of debate. Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is a tool used to identify and risk-stratifyPNETs. This study investigates the concordance rate of Ki67 grading between EUS-FNA and surgical pathology specimens in NF-PNETs and whether certain NF-PNET characteristics are associated with disease recurrence and disease-related death. Methods: We retrospectively reviewed the clinical history, imaging, endoscopic findings, and pathology records of 37 cases of NF-PNETs that underwent pre-operative EUS-FNA and surgical resection at a single academic medical center. Results: There was 73% concordance between Ki67 obtained from EUS-FNA cytology and surgical pathology specimens; concordancewas the highest for low- and high-grade NF-PNETs. High-grade Ki67 NF-PNETs based on cytology (p=0.028) and histology (p=0.028)were associated with disease recurrence and disease-related death. Additionally, tumors with high-grade mitotic rate (p=0.005), tumorsize >22.5 mm (p=0.104), and lymphovascular invasion (p=0.103) were more likely to have poor prognosis. Conclusions: NF-PNETs with high-grade Ki67 on EUS-FNA have poor prognosis despite surgical resection. NF-PNETs withintermediate-grade Ki67 on EUS-FNA should be strongly considered for surgical resection. NF-PNETs with low-grade Ki67 on EUS-FNA can be monitored without surgical intervention, up to tumor size 20 mm.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Halfdanarson TR / 2008 / Pancreatic endocrine neoplasms : epidemiology and prognosis of pancreatic endocrine tumors / Endocr Relat Cancer 15:409~427
Metz DC / 2008 / Gastrointestinal neuroendocrine tumors : pancreatic endocrine tumors / Gastroenterology 135:1469~1492
Grimelius L / 1975 / Cytological differentiation of asymptomatic pancreatic islet cell tumours in autopsy material / Virchows Arch A Pathol Anat Histol 365:275~288
Kimura W / 1991 / Clinical pathology of endocrine tumors of the pancreas. Analysis of autopsy cases / Dig Dis Sci 36:933~942
Halfdanarson TR / 2008 / Pancreatic neuroendocrine tumors(PNETs) : incidence, prognosis and recent trend toward improved survival / Ann Oncol 19:1727~1733
Metz DC / 2008 / Gastrointestinal neuroendocrine tumors : pancreatic endocrine tumors / Gastroenterology 135:1469~1492
Grimelius L / 1975 / Cytological differentiation of asymptomatic pancreatic islet cell tumours in autopsy material / Virchows Arch A Pathol Anat Histol 365:275~288
Kimura W / 1991 / Clinical pathology of endocrine tumors of the pancreas. Analysis of autopsy cases / Dig Dis Sci 36:933~942
Halfdanarson TR / 2008 / Pancreatic neuroendocrine tumors(PNETs) : incidence, prognosis and recent trend toward improved survival / Ann Oncol 19:1727~1733
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