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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 490 - 496 (7page)
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초록· 키워드
오류제보하기
ObjectiveSeveral studies have examined biological markers during the first trimester to predict the maintenance of a healthypregnancy. One such marker is kisspeptin, which is encoded by the KISS-1 gene. We aimed to determine whether first-trimester pregnancy losses were associated with levels of placental KISS-1 expression. MethodsThis prospective case control study was conducted at a tertiary center. The study group included 27 and 24 patientswho underwent dilation and curettage at <10 weeks of gestation, due to first trimester spontaneous pregnancy lossand for elective termination (control), respectively. Placental and decidual tissues from all patients were sectioned andimmunohistochemically analyzed for kisspeptin. ResultsAge, gravida status, parity number, gestational week, and number of previous abortions did not significantly differbetween the groups. KISS-1 expression levels were significantly lower in the group with spontaneous abortioncompared with the group with elective termination. The median staining intensity of KISS-1 expression in the electiveand spontaneous termination groups were 3 (strong) and 2 (moderate), respectively (P=0.004). KISS-1 expression levelswere significantly lower among patients with previous abortions in the elective termination group (P=0.002). ConclusionKISS-1 expression levels were found to be significantly reduced in patients with spontaneous pregnancy loss; KISS-1plays an important role in the implantation and continuation of pregnancy.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Liu Y / 2015 / Etiology of spontaneous abortion before and after the demonstration of embryonic cardiac activity in women with recurrent spontaneous abortion / Int J Gynaecol Obstet 129:128~132
Shih IM / 1997 / New concepts in trophoblastic growth and differentiation with practical application for the diagnosis of gestational trophoblastic disease / Verh Dtsch Ges Pathol 81:266~272
Norwitz ER / 2001 / Implantation and the survival of early pregnancy / N Engl J Med 345:1400~1408
Cignini P / 2016 / Predictive value of pregnancy-associated plasma protein-A(PAPP-A)and free betahCG on fetal growth restriction : results of a prospective study / Arch Gynecol Obstet 293:1227~1233
Sonek J / 2018 / First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume / Am J Obstet Gynecol 218:126.e1~126.e13
Shih IM / 1997 / New concepts in trophoblastic growth and differentiation with practical application for the diagnosis of gestational trophoblastic disease / Verh Dtsch Ges Pathol 81:266~272
Norwitz ER / 2001 / Implantation and the survival of early pregnancy / N Engl J Med 345:1400~1408
Cignini P / 2016 / Predictive value of pregnancy-associated plasma protein-A(PAPP-A)and free betahCG on fetal growth restriction : results of a prospective study / Arch Gynecol Obstet 293:1227~1233
Sonek J / 2018 / First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume / Am J Obstet Gynecol 218:126.e1~126.e13
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