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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 521 - 528 (8page)
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초록· 키워드
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ObjectiveTo investigate whether serum 25-hydroxyvitamin D [25(OH)D] level is associated with ovarian reserve markers insecondary amenorrhea (SA) patients. MethodsSixty-three women diagnosed with SA were recruited during 12 months from the initiation of this prospectiveobservational study. Serum 25(OH)D levels, serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC)were estimated in study participants and ovarian reserve markers were compared between participants with vitaminD deficiency and those with normal vitamin D levels. ResultsOf the 63 participants, 27 (42.9%) were vitamin D deficient (<20 ng/mL) and 36 (57.1%) had normal vitamin D levels. The mean AMH levels and AFC were 10.86±8.94 µ/L and 15.23±7.65 in the vitamin D deficient group, and 7.24±5.62 µ/Land 12.30±6.95 in the normal vitamin D group. Univariate and multivariate linear regression analysis of log10transformed AMH and AFC with serum 25(OH)D adjusted for age and body mass index confirmed no associationbetween vitamin D levels and AMH levels or AFC. There was also no correlation between serum 25(OH)D and AMHlevels or AFC in all participants. However, participants with vitamin D deficiency had an increased chance of havingpolycystic ovarian syndrome (PCOS) as cause of SA than those with normal vitamin D levels (adjusted odds ratio, 7.559;95% confidence interval, 1.28–44.65; P=0.026) after adjustment for clinical factors by logistic regression model. ConclusionThere was no correlation between serum 25(OH)D levels and ovarian reserve markers in SA patients, but vitamin Ddeficiency may be linked to PCOS patients.
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참고문헌 (26)
참고문헌 신청
Fabris A / 2014 / Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients / Fertil Steril 102:1608~1612
van de Vijver A / 2016 / Vitamin D deficiency and pregnancy rates following frozen-thawed embryo transfer : a prospective cohort study / Hum Reprod 31:1749~1754
Franasiak JM / 2015 / Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts / Am J Obstet Gynecol 212:315.e1~6
Yoshizawa T / 1997 / Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning / Nat Genet 16:391~396
Parikh G / 2010 / Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1(IGFBP-1)production in human ovarian cells / Horm Metab Res 42:754~757
van de Vijver A / 2016 / Vitamin D deficiency and pregnancy rates following frozen-thawed embryo transfer : a prospective cohort study / Hum Reprod 31:1749~1754
Franasiak JM / 2015 / Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts / Am J Obstet Gynecol 212:315.e1~6
Yoshizawa T / 1997 / Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning / Nat Genet 16:391~396
Parikh G / 2010 / Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1(IGFBP-1)production in human ovarian cells / Horm Metab Res 42:754~757
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