지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 205 - 208 (4page)
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초록· 키워드
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A 50-year-old non-Hispanic white Caucasian female was diagnosed with breast cancer and was subsequentlyfound to possess the tumorigenic ataxia telangiectasia mutated (ATM) and PALB2 variants but not the BRCA1 andBRCA2 variants. She visited the gynecologic oncology office for routine counseling about risk-reducing salpingooophorectomy(RRSO). Although the patient was asymptomatic, an adnexal mass was discovered in the physicalexamination performed by palpation. Upon using pre-operative imaging techniques, an 8 cm complex adnexal masswas identified. Her CA-125 level was elevated. She underwent complete cytoreductive surgery. Pathological analysisshowed a stage IC clear cell carcinoma of the left ovary; subsequently, she received 6 cycles of adjuvant chemotherapywith a combination of carboplatin and paclitaxel. The patient exhibited no signs ovarian cancer in a follow-upappointment after 32 months of treatment. However, bilateral RRSO is not recommended for patients positive forATM and PALB2. Breast cancer patients with PALB2 and ATM mutations should extensively discuss the risks andbenefits of RRSO in light of current data.
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참고문헌 (15)
참고문헌 신청
Siegel RL / 2019 / Cancer statistics, 2019 / CA Cancer J Clin 69:7~34
NCCN / 2018 / Genetic/familial high-risk assessment: breast and ovarian cancer. Version 2.2019 / National Comprehensive Cancer Network
Kim HS / 2014 / Risk and prognosis of ovarian cancer in women with endometriosis : a meta-analysis / Br J Cancer 110:1878~1890
Gay GM / 2015 / Reproductive factors, adiposity, breastfeeding and their associations with ovarian cancer in an Asian cohort / Cancer Causes Control 26:1561~1573
Kurian AW / 2019 / Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients / J Clin Oncol 37:1305~1315
NCCN / 2018 / Genetic/familial high-risk assessment: breast and ovarian cancer. Version 2.2019 / National Comprehensive Cancer Network
Kim HS / 2014 / Risk and prognosis of ovarian cancer in women with endometriosis : a meta-analysis / Br J Cancer 110:1878~1890
Gay GM / 2015 / Reproductive factors, adiposity, breastfeeding and their associations with ovarian cancer in an Asian cohort / Cancer Causes Control 26:1561~1573
Kurian AW / 2019 / Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients / J Clin Oncol 37:1305~1315
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