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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제4호
- 발행연도
- 2020.1
- 수록면
- 591 - 598 (8page)
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초록· 키워드
오류제보하기
Lactobacillus plantarum KU15149 was demonstrated to have probiotic behavior and functions, including antioxidant and anti-inflammatory activity. L. plantarum KU15149 obtained from homemade diced-radish kimchi has a high survival rate under artificial gastric acid (pH 2.5, 0.3% pepsin) and bile salt (0.3% oxgall) conditions. However, L. plantarum KU15149 did not produce β-glucuronidase, which is known to be a carcinogenic enzyme with resistance to several antibiotics, such as gentamycin, kanamycin, streptomycin, tetracycline, and ciprofloxacin. L. plantarum KU15149 strongly adhered to HT-29 cells and had high antioxidant activity in terms of 2,2-diphenyl- 1-picrylhydrazyl (DPPH) free radical-scavenging and β-carotene bleaching assays. L. plantarum KU15149 also exhibited a pronounced inhibition of nitric oxide (NO) production, along with expression of nitric oxide synthase (iNOS) and cyclooxygenase -2 (COX-2) as well as proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6, when RAW 264.7 cells were stimulated with LPS. Therefore, L. plantarum KU15149 exhibited pharmaceutical functionality as a potential probiotic.
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참고문헌 (36)
참고문헌 신청
Rahman T / 2012 / Oxidative stress and human health / Adv. Biosci. Biotechnol 3:997~1019
Carocho M / 2013 / A review on antioxidants, prooxidants and related controversy : natural and synthetic compounds, screening and analysis methodologies and future perspectives / Food Chem. Toxicol 51:15~25
Dröge W / 2002 / Free radicals in the physiological control of cell function / Physiol. Rev 82:47~95
Lawrence T / 2002 / Anti-inflammatory lipid mediators and insights into the resolution of inflammation / Nat. Rev. Immunol 2:787~795
Duque GA / 2014 / Macrophage Cytokines : Involvement in immunity and infectious diseases / Front Immunol 5:491
Carocho M / 2013 / A review on antioxidants, prooxidants and related controversy : natural and synthetic compounds, screening and analysis methodologies and future perspectives / Food Chem. Toxicol 51:15~25
Dröge W / 2002 / Free radicals in the physiological control of cell function / Physiol. Rev 82:47~95
Lawrence T / 2002 / Anti-inflammatory lipid mediators and insights into the resolution of inflammation / Nat. Rev. Immunol 2:787~795
Duque GA / 2014 / Macrophage Cytokines : Involvement in immunity and infectious diseases / Front Immunol 5:491
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