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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제4호
- 발행연도
- 2020.1
- 수록면
- 583 - 590 (8page)
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초록· 키워드
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Deinococcus actinosclerus BM2T (GenBank: KT448814) is a radio-resistant bacterium that is newly isolated from the soil of a rocky hillside in Seoul. As an extremophile, D. actinosclerus BM2T may possess anti-inflammatory properties that may be beneficial to human health. In this study, we evaluated the anti-inflammatory effects of BM2U, an aqueous extract of D. actinosclerus BM2T, on lipopolysaccharide (LPS)-mediated inflammatory responses in RAW264.7 macrophage cells. BM2U showed antioxidant capacity, as determined by the DPPH radical scavenging (IC50 = 349.3 μg/ml) and ORAC (IC50 = 50.24 μg/ml) assays. At 20 μg/ml, BM2U induced a significant increase in heme oxygenase-1 (HO-1) expression (p < 0.05). BM2U treatment (0.2-20 μg/ml) significantly suppressed LPS-induced increase in the mRNA expression of proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 (p < 0.05). BM2U treatment also suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which are involved in the production of inflammatory mediators. BM2U treatment also inhibited the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs): JNK, ERK, and p-38 (p < 0.05). Collectively, BM2U exhibited anti-inflammatory potential that can be exploited in attenuating inflammatory responses.
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참고문헌 (32)
참고문헌 신청
Ferrero-Miliani L / 2007 / Chronic inflammation : importance of NOD2 and NALP3 in interleukin-1β generation / Clin. Exp. Immunol 147:227~235
Chen GY / 2010 / Sterile inflammation : sensing and reacting to damage / Nat. Rev. Immunol 10:826~837
Seki E / 2015 / Hepatic inflammation and fibrosis : functional links and key pathways / Hepatology 61:1066~1079
Ben Salem C / 2015 / Fibrosis--A common pPathway to organ injury and failure / N. Engl. J. Med 373:95
Hunter P / 2012 / The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment / EMBO Rep. 13:968~970
Chen GY / 2010 / Sterile inflammation : sensing and reacting to damage / Nat. Rev. Immunol 10:826~837
Seki E / 2015 / Hepatic inflammation and fibrosis : functional links and key pathways / Hepatology 61:1066~1079
Ben Salem C / 2015 / Fibrosis--A common pPathway to organ injury and failure / N. Engl. J. Med 373:95
Hunter P / 2012 / The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment / EMBO Rep. 13:968~970
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