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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제10호
- 발행연도
- 2019.1
- 수록면
- 1,570 - 1,579 (10page)
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초록· 키워드
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The fungal products dibenzodioxocinones promise a novel class of inhibitors against cholesterol ester transfer protein (CEPT). Knowledge as to their biosynthesis is scarce. In this report, we characterized four more dibenzodioxocinones, which along with a previously described member pestalotiollide B, delimit the dominant spectrum of secondary metabolites in P. microspora. Through mRNA-seq profiling in gα1Δ, a process that halts the production of the dibenzodioxocinones, a gene cluster harboring 21 genes including a polyketide synthase, designated as pks8, was defined. Disruption of genes in the cluster led to loss of the compounds, concluding the anticipated role in the biosynthesis of the chemicals. The biosynthetic route to dibenzodioxocinones was temporarily speculated. This study reveals the genetic basis underlying the biosynthesis of dibenzodioxocinone in fungi, and may facilitate the practice for yield improvement in the drug development arena.
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참고문헌 (29)
참고문헌 신청
Kawahara T / 2013 / Three eremophilane derivatives, MBJ-0011, MBJ-0012 and MBJ-0013, from an endophytic fungus Apiognomonia sp. f24023 / J. Antibiot 66:299~302
Lin ZJ / 2008 / Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum / Phytochemistry 69:1273~1278
Challinor VL / 2015 / Bioactive natural products from novel microbial sources / Ann. NY Acad. Sci 1354:82~97
Hu Y / 2017 / NAD+-dependent HDAC inhibitor stimulates Monascus pigment production but inhibit citrinin / AMB Express 7:116
Xu J / 2009 / Chromones from the endophytic fungus Pestalotiopsis sp, Isolated from the Chinese mangrove plant Rhizophora mucronata / J. Nat. Prod 72:662~665
Lin ZJ / 2008 / Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum / Phytochemistry 69:1273~1278
Challinor VL / 2015 / Bioactive natural products from novel microbial sources / Ann. NY Acad. Sci 1354:82~97
Hu Y / 2017 / NAD+-dependent HDAC inhibitor stimulates Monascus pigment production but inhibit citrinin / AMB Express 7:116
Xu J / 2009 / Chromones from the endophytic fungus Pestalotiopsis sp, Isolated from the Chinese mangrove plant Rhizophora mucronata / J. Nat. Prod 72:662~665
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