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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 431 - 437 (7page)
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초록· 키워드
오류제보하기
The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage. Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via the circulating concentrations of metabolic hormones and nutrients, and then coordinate energy intake and expenditure to maintain energy homeostasis. Malfunction or loss of hypothalamic ARH neurons results in obesity. Accumulated evidence suggests that hypothalamic inflammation is a key pathological mechanism that links chronic overconsumption of a high-fat diet (HFD) with the development of obesity and related metabolic complications. Interestingly, overnutrition-induced hypothalamic inflammation occurs specifically in the ARH, where microglia initiate an inflammatory response by releasing proinflammatory cytokines and chemokines in response to excessive fatty acid flux. Upon more prolonged HFD consumption, astrocytes and perivascular macrophages become involved and sustain hypothalamic inflammation. ARH neurons are victims of hypothalamic inflammation, but they may actively participate in hypothalamic inflammation by sending quiescence or stress signals to surrounding glia. In this mini-review, we describe the current state of knowledge regarding the contributions of neurons and glia, and their interactions, to HFD-induced hypothalamic inflammation.
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참고문헌 (45)
참고문헌 신청
Abbott, N. J. / 2006 / Astrocyte-endothelial interactions at the blood-brain barrier / Nat. Rev. Neurosci 7:41~53
Allan, S. M. / 2001 / Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1 / Brain Res. Mol. Brain Res 93:180~189
Allen, A. R. / 2013 / Effects of radiation combined injury on hippocampal function are modulated in mice deficient in chemokine receptor 2(CCR2) / Radiat. Res 180:78~88
Argaw, A. T. / 2012 / Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease / J. Clin. Invest 122:2454~2468
Benarroch, E. E / 2005 / Neuron-astrocyte interactions : partnership for normal function and disease in the central nervous system / Mayo Clin Proc 80:1326~1338
Allan, S. M. / 2001 / Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1 / Brain Res. Mol. Brain Res 93:180~189
Allen, A. R. / 2013 / Effects of radiation combined injury on hippocampal function are modulated in mice deficient in chemokine receptor 2(CCR2) / Radiat. Res 180:78~88
Argaw, A. T. / 2012 / Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease / J. Clin. Invest 122:2454~2468
Benarroch, E. E / 2005 / Neuron-astrocyte interactions : partnership for normal function and disease in the central nervous system / Mayo Clin Proc 80:1326~1338
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