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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 142 - 147 (6page)
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Lipid accumulation in white adipose tissue is the key contributor to the obesity and orchestrates numerous metabolic health problems such as type 2 diabetes, hypertension, atherosclerosis, and cancer. Nonetheless, the prevention and treatment of obesity are still inadequate. Recently, scientists found that brown adipose tissue (BAT) in adult humans has functions that are diametrically opposite to those of white adipose tissue and that BAT holds promise for a new strategy to counteract obesity. In this study, we evaluated the potential of sinapic acid (SA) to promote the thermogenic program and lipolysis in BAT. SA treatment of brown adipocytes induced the expression of brown-adipocyte activation–related genes such as Ucp1, Pgc-1, and Prdm16. Furthermore, structural analysis and western blot revealed that SA upregulates protein kinase A (PKA) phosphorylation with competitive inhibition by a pan-PKA inhibitor, H89. SA binds to the adenosine triphosphate (ATP) site on the PKA catalytic subunit where H89 binds specifically. PKA-cat-1 gene–silencing experiments confirmed that SA activates the thermogenic program via a mechanism involving PKA and cyclic AMP response element–binding protein (CREB) signaling. Moreover, SA treatment promoted lipolysis via a PKA/p38-mediated pathway. Our findings may allow us to open a new avenue of strategies against obesity and need further investigation.
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참고문헌 (33)
참고문헌 신청
Vijgen GH / 2013 / Increased oxygen consumption in human adipose tissue from the"brown adipose tissue"region / J Clin Endocrinol Metab 98:E1230~E1234
Nedergaard J / 2001 / UCP1 : the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency / Biochim Biophys Acta Bioenerg 1504:82~106
Chondronikola M / 2014 / Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans / Diabetes 63:4089~4099
Saito M / 2016 / Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans / Best Pract Res Clin Endocrinol Metab 30:537~547
Uldry M / 2006 / Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation / Cell Metab 3:333~341
Nedergaard J / 2001 / UCP1 : the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency / Biochim Biophys Acta Bioenerg 1504:82~106
Chondronikola M / 2014 / Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans / Diabetes 63:4089~4099
Saito M / 2016 / Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans / Best Pract Res Clin Endocrinol Metab 30:537~547
Uldry M / 2006 / Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation / Cell Metab 3:333~341
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