Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants

Maria Elisabetta Baldassarre; Antonio Di Mauro; Silvia Salvatore; Silvio Tafuri; Francesco Paolo Bianchi; Enzo Dattoli; Lucia Morando; Licia Pensabene; Fabio Meneghin; Dario Dilillo; Valentina Mancini; Valentina Talarico; Francesco Tandoi; Gianvincenzo Zuccotti; Massimo Agosti; Nicola Laforgia

Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants

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Type: Academic journal

Author: Maria Elisabetta Baldassarre Antonio Di Mauro Silvia Salvatore Silvio Tafuri Francesco Paolo Bianchi Enzo Dattoli Lucia Morando Licia Pensabene Fabio Meneghin Dario Dilillo Valentina Mancini Valentina Talarico Francesco Tandoi Gianvincenzo Zuccotti Massimo Agosti Nicola Laforgia

Journal: The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제23권 제4호 KCI Accredited Journals

Published: 2020.1

Pages: 366 - 376 (11page)

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Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants

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Purpose: To assess the association between birth weight and the development of functional gastrointestinal disorders (FGIDs) in the first year of life. Methods: This is a secondary analysis of a prospective cohort multicenter study including neonates, consecutively enrolled at birth, and followed up for one year. At birth all infants were classified by birth weight as extremely low (ELBW), very low, or low when <1,000, <1,500, and <2,500 g, respectively, and by birth weight for gestational age as appropriate (AGA, weight in the 10–90th percentile), small (SGA, weight <10th percentile), and large (LGA, weight >90th percentile) for gestational age. FGIDs were classified according to the Rome III criteria and assessed at 1, 3, 6, and 12 months of life. Results: Among 1,152 newborns enrolled, 934 (81.1%) completed the study: 302 (32.3%) were preterm, 35 (3.7%) were ELBW, 104 (11.1%) were SGA, 782 (83.7%) were AGA, and 48 (5.1%) were LGA infants. Overall, throughout the first year of life, 718 (76.9%) reported at least one FGID. The proportion of infants presenting with at least one FGID was significantly higher in ELBW (97%) compared to LBW (74%) (p=0.01) and in LGA (85.4%) and SGA (85.6%) compared to AGA (75.2%) (p=0.0001). On multivariate analysis, SGA was significantly associated with infantile colic. Conclusion: We observed an increased risk of FGIDs in ELBW, SGA, and LGA neonates. Our results suggest that prenatal factors determining birth weight may influence the development of FGIDs in infants. Understanding the role of all potential risk factors may provide new insights and targeted approaches for FGIDs.

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References (43)

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Baldassarre ME / 2017 / Non-communicable chronic diseases : the role of neonatal characteristics / Iran J Pediatr 27:e9322

Salvatore S / 2019 / Neonatal antibiotics and prematurity are associated with an increased risk of functional gastrointestinal disorders in the first year of life / J Pediatr 212:44~51

Søndergaard C / 2000 / Fetal growth and infantile colic / Arch Dis Child Fetal Neonatal Ed 83:F44~7

Yvan Vandenplas / 2019 / Functional Gastrointestinal Disorders in Infancy: Impact on the Health of the Infant and Family / Pediatric Gastroenterology, Hepatology & Nutrition 22(3):207~216

Mahon J / 2017 / The costs of functional gastrointestinal disorders and related signs and symptoms in infants : a systematic literature review and cost calculation for England / BMJ Open 7:e015594

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